{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thai NM"],"funding":["Hue University under the Core Research Program","Cooperative Research Programme between Institute of Applied Research in Science and Technology, University of Sciences, Hue University and KeFa Science and Technology Co., Ltd","Hue Unversity"],"pagination":["292"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10403485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(9)"],"pubmed_abstract":["Laboratory experiments were carried out to identify the chemical composition of <i>Cordyceps militaris</i> and reveal the first evidence of their Alzheimer-related potential. Liquid chromatography-mass spectrometry analysis identified 21 bioactive compounds in the ethanol extract (<b>1-21</b>). High-performance liquid chromatography quantified the content of cordycepin (0.32%). Bioassays revealed the overall anti-Alzheimer potential of the extract against acetylcholinesterase (IC<sub>50</sub> = 115.9 ± 11.16 µg mL<sup>-1</sup>). Multi-platform computations were utilized to predict the biological inhibitory effects of its phytochemical components against Alzheimer-related protein structures: acetylcholinesterase (PDB-4EY7) and β-amyloid protein (PDB-2LMN). In particular, <b>7</b> is conside"],"journal":["3 Biotech"],"pubmed_title":["Identification of potential inhibitors against Alzheimer-related proteins in <i>Cordyceps militaris</i> ethanol extract: experimental evidence and computational analyses."],"pmcid":["PMC10403485"],"funding_grant_id":["DHH2022-01-198","NCM.DHH.2020.04"],"pubmed_authors":["Hai NTT","Nhung NTA","Triet NT","De Tran V","Bui TQ","Thai NM","Phu NV","Dat TTH","Quy PT","Pham DT"],"additional_accession":[]},"is_claimable":false,"name":"Identification of potential inhibitors against Alzheimer-related proteins in <i>Cordyceps militaris</i> ethanol extract: experimental evidence and computational analyses.","description":"Laboratory experiments were carried out to identify the chemical composition of <i>Cordyceps militaris</i> and reveal the first evidence of their Alzheimer-related potential. Liquid chromatography-mass spectrometry analysis identified 21 bioactive compounds in the ethanol extract (<b>1-21</b>). High-performance liquid chromatography quantified the content of cordycepin (0.32%). Bioassays revealed the overall anti-Alzheimer potential of the extract against acetylcholinesterase (IC<sub>50</sub> = 115.9 ± 11.16 µg mL<sup>-1</sup>). Multi-platform computations were utilized to predict the biological inhibitory effects of its phytochemical components against Alzheimer-related protein structures: acetylcholinesterase (PDB-4EY7) and β-amyloid protein (PDB-2LMN). In particular, <b>7</b> is conside","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-04T06:49:44.838Z","creation":"2025-04-06T13:45:18.71Z"},"accession":"S-EPMC10403485","cross_references":{"pubmed":["37547918"],"doi":["10.1007/s13205-023-03714-9"]}}