biostudies-literatureUnknown15(1)Yaghoobi M<b>Background:</b> Studies on the use of fecal immunochemical test (FIT) in colorectal screening have long assumed perfect accuracy for colonoscopy. No study to date has directly compared the diagnostic accuracy of colonoscopy and FIT to detect advanced neoplasia (AN) in a head-to-head diagnostic accuracy meta-analysis. <b>Methods:</b> A comprehensive electronic search was performed for a head-to-head comparison of FIT and colonoscopy using a third acceptable reference standard in asymptomatic adults. Cochrane methodology was used to perform a head-to-head diagnostic test accuracy (DTA) meta-analysis. Quality assessment tool for diagnostic accuracy studies-2 (QUADAS-2) was used to assess the risk of bias in included studies. <b>Results:</b> Two studies met the eligibility criteria. OverallMiddle East journal of digestive diseases5-11https://www.ebi.ac.uk/biostudies/studies/S-EPMC10404074biostudies-literatureHead-to-Head Diagnostic Test Accuracy Meta-analysis of Colonoscopy and Fecal Immunochemical Test in Detecting Advanced Colon Neoplasia.PMC10404074Mehraban Far PMoayyedi PYaghoobi MMbuagbaw LArmstrong DYuan YThabane LfalseHead-to-Head Diagnostic Test Accuracy Meta-analysis of Colonoscopy and Fecal Immunochemical Test in Detecting Advanced Colon Neoplasia.<b>Background:</b> Studies on the use of fecal immunochemical test (FIT) in colorectal screening have long assumed perfect accuracy for colonoscopy. No study to date has directly compared the diagnostic accuracy of colonoscopy and FIT to detect advanced neoplasia (AN) in a head-to-head diagnostic accuracy meta-analysis. <b>Methods:</b> A comprehensive electronic search was performed for a head-to-head comparison of FIT and colonoscopy using a third acceptable reference standard in asymptomatic adults. Cochrane methodology was used to perform a head-to-head diagnostic test accuracy (DTA) meta-analysis. Quality assessment tool for diagnostic accuracy studies-2 (QUADAS-2) was used to assess the risk of bias in included studies. <b>Results:</b> Two studies met the eligibility criteria. Overall2023-01-01T00:00:00Z2023 Jan2025-04-05T14:51:41.693Z2025-04-05T14:51:41.693ZS-EPMC104040743754715810.34172/mejdd.2023.313