biostudies-literatureUnknown10(6)Xue QPost-translational modifications (PTM) are covalent modifications of proteins or peptides caused by proteolytic cleavage or the attachment of moieties to one or more amino acids. PTMs play essential roles in biological function and regulation and have been linked with several diseases. Modifications of protein acylation (Kac), a type of PTM, are known to induce epigenetic regulatory processes that promote various diseases. Thus, an increasing number of studies focusing on acylation modifications are being undertaken. Butyrylation (Kbu) is a new acylation process found in animals and plants. Kbu has been recently linked to the onset and progression of several diseases, such as cancer, cardiovascular diseases, diabetes, and vascular dementia. Moreover, the mode of action of certain drugs useGenes & diseases2479-2490https://www.ebi.ac.uk/biostudies/studies/S-EPMC10404885biostudies-literatureFunctions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases.PMC10404885Li HLi XYang YZou LLi TQi HXue QMa HYu TWang JfalseFunctions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases.Post-translational modifications (PTM) are covalent modifications of proteins or peptides caused by proteolytic cleavage or the attachment of moieties to one or more amino acids. PTMs play essential roles in biological function and regulation and have been linked with several diseases. Modifications of protein acylation (Kac), a type of PTM, are known to induce epigenetic regulatory processes that promote various diseases. Thus, an increasing number of studies focusing on acylation modifications are being undertaken. Butyrylation (Kbu) is a new acylation process found in animals and plants. Kbu has been recently linked to the onset and progression of several diseases, such as cancer, cardiovascular diseases, diabetes, and vascular dementia. Moreover, the mode of action of certain drugs use2023-01-01T00:00:00Z2023 Nov2025-04-22T13:39:00.288Z2025-04-06T00:42:56.65ZS-EPMC104048853755420210.1016/j.gendis.2022.10.025