{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang F"],"funding":["Natural Science Foundation of Chongqing Municipality","Natural Science Foundation Project of Chongqing","Postdoctoral Research Foundation of China","National Natural Science Foundation of China","Chongqing Postdoctoral Science Foundation"],"pagination":["2622-2638"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10404965"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Protein arginine methyltransferase 1 (PRMT1), a type I PRMT, is overexpressed in gastric cancer (GC) cells. To elucidate the function of PRMT1 in GC, PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA (shRNA) or inhibited by PRMT1 inhibitors (AMI-1 or DCLX069), which resulted in inhibition of GC cell proliferation, migration, invasion, and tumorigenesis <i>in vitro</i> and <i>in vivo</i>. MLX-interacting protein (MLXIP) and Kinectin 1 (KTN1) were identified as PRMT1-binding proteins. PRMT1 recruited MLXIP to the promoter of β-catenin, which induced β-catenin transcription and activated the β-catenin signaling pathway, promoting GC cell migration and metastasis. Furthermore, KTN1 inhibited the K48-linked ubiquitination of PRMT1 by decreasing the interaction be"],"journal":["Genes & diseases"],"pubmed_title":["PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway."],"pmcid":["PMC10404965"],"funding_grant_id":["cstc2022ycjh-bgzxm0145","cstc2021jcyj-bsh0067","82203339","7820100607","2021M692679"],"pubmed_authors":["Yang H","Ke X","Lu M","Liang H","Peng S","Wang F","Cui H","Zhong X","Chen S","Zhou X","Tang H"],"additional_accession":[]},"is_claimable":false,"name":"PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway.","description":"Protein arginine methyltransferase 1 (PRMT1), a type I PRMT, is overexpressed in gastric cancer (GC) cells. To elucidate the function of PRMT1 in GC, PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA (shRNA) or inhibited by PRMT1 inhibitors (AMI-1 or DCLX069), which resulted in inhibition of GC cell proliferation, migration, invasion, and tumorigenesis <i>in vitro</i> and <i>in vivo</i>. MLX-interacting protein (MLXIP) and Kinectin 1 (KTN1) were identified as PRMT1-binding proteins. PRMT1 recruited MLXIP to the promoter of β-catenin, which induced β-catenin transcription and activated the β-catenin signaling pathway, promoting GC cell migration and metastasis. Furthermore, KTN1 inhibited the K48-linked ubiquitination of PRMT1 by decreasing the interaction be","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-05T14:51:49.203Z","creation":"2025-04-05T14:51:49.203Z"},"accession":"S-EPMC10404965","cross_references":{"pubmed":["37554218"],"doi":["10.1016/j.gendis.2023.02.006"]}}