biostudies-literatureUnknown12(4)Wilson-Smith AR<h4>Background</h4>Valve-sparing aortic procedures, including the David and Yacoub procedures, have emerged as the dominant approaches in aortic aneurysm surgery, preserving the native aortic valve and thereby conferring significant prognostic benefits to the patient. Over the years, these procedures have also shown promise in patients with bicuspid valve-related aortopathy. This systematic review and meta-analysis presents the most up-to-date data on perioperative outcomes, freedom from secondary reoperation, and freedom from mortality for bicuspid valve patients undergoing valve-sparing aortic operations.<h4>Methods</h4>The methods for this systematic review and meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Four databases were Annals of cardiothoracic surgery286-294https://www.ebi.ac.uk/biostudies/studies/S-EPMC10405344biostudies-literatureThe outcomes of three decades of the David and Yacoub procedures in bicuspid aortic valve patients-a systematic review and meta-analysis.PMC10405344Williams MLEranki AMuston BTWilson-Smith ARStrode Smith JNg DWilson-Smith CJfalseThe outcomes of three decades of the David and Yacoub procedures in bicuspid aortic valve patients-a systematic review and meta-analysis.<h4>Background</h4>Valve-sparing aortic procedures, including the David and Yacoub procedures, have emerged as the dominant approaches in aortic aneurysm surgery, preserving the native aortic valve and thereby conferring significant prognostic benefits to the patient. Over the years, these procedures have also shown promise in patients with bicuspid valve-related aortopathy. This systematic review and meta-analysis presents the most up-to-date data on perioperative outcomes, freedom from secondary reoperation, and freedom from mortality for bicuspid valve patients undergoing valve-sparing aortic operations.<h4>Methods</h4>The methods for this systematic review and meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Four databases were 2023-01-01T00:00:00Z2023 Jul2025-04-27T00:09:12.905Z2025-04-06T17:46:23.893ZS-EPMC104053443755471010.21037/acs-2023-avs2-19