{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim JH"],"funding":["National Institute of Horticultural and Herbal Scienses, RDA"],"pagination":["2242704"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10405751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(1)"],"pubmed_abstract":["Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. <i>In vitro</i> and <i>in silico</i>, compounds <b>1</b>-<b>3</b> from <i>Glycyrrhiza uralensis</i> had inhibitory activity and binding affinity for 3CLpro. These compounds decreased HCoV-OC43 cytotoxicity in RD cells. Moreover, they inhibited viral growth by reducing the amounts of the necessary proteins (M, N, and RDRP). Therefore, compounds <b>1</b>-<b>3</b> are inhibitors of 3CLpro and HCoV-OC43 proliferation."],"journal":["Journal of enzyme inhibition and medicinal chemistry"],"pubmed_title":["Inhibition by components of <i>Glycyrrhiza uralensis</i> of 3CLpro and HCoV-OC43 proliferation."],"pmcid":["PMC10405751"],"funding_grant_id":["PJ016777032023"],"pubmed_authors":["Huh YC","Park WT","Kim TI","Park J","Park YI","Moon YH","Kim JH","Kang MH","Cho CW","Kang JS","Hur M"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition by components of <i>Glycyrrhiza uralensis</i> of 3CLpro and HCoV-OC43 proliferation.","description":"Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. <i>In vitro</i> and <i>in silico</i>, compounds <b>1</b>-<b>3</b> from <i>Glycyrrhiza uralensis</i> had inhibitory activity and binding affinity for 3CLpro. These compounds decreased HCoV-OC43 cytotoxicity in RD cells. Moreover, they inhibited viral growth by reducing the amounts of the necessary proteins (M, N, and RDRP). Therefore, compounds <b>1</b>-<b>3</b> are inhibitors of 3CLpro and HCoV-OC43 proliferation.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-29T10:23:26.611Z","creation":"2025-04-04T20:01:01.409Z"},"accession":"S-EPMC10405751","cross_references":{"pubmed":["37537881"],"doi":["10.1080/14756366.2023.2242704"]}}