{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Smith DA"],"funding":["Swiss National Science Foundation","NHGRI NIH HHS","National Institutes of Health","Fulbright Association","NIGMS NIH HHS"],"pagination":["e18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10406571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1"],"pubmed_abstract":["Pharmacogenetics, the study of how interindividual genetic differences affect drug response, does not explain all observed heritable variance in drug response. Epigenetic mechanisms, such as DNA methylation, and histone acetylation may account for some of the unexplained variances. Epigenetic mechanisms modulate gene expression and can be suitable drug targets and can impact the action of nonepigenetic drugs. Pharmacoepigenetics is the field that studies the relationship between epigenetic variability and drug response. Much of this research focuses on compounds targeting epigenetic mechanisms, called epigenetic drugs, which are used to treat cancers, immune disorders, and other diseases. Several studies also suggest an epigenetic role in classical drug response; however, we know little ab"],"journal":["Cambridge prisms. Precision medicine"],"pubmed_title":["Promises and challenges in pharmacoepigenetics."],"pmcid":["PMC10406571"],"funding_grant_id":["U24 HG010615","R01 GM102365","GM102365","HG010615","310030","189147"],"pubmed_authors":["Smith DA","Sadler MC","Altman RB"],"additional_accession":[]},"is_claimable":false,"name":"Promises and challenges in pharmacoepigenetics.","description":"Pharmacogenetics, the study of how interindividual genetic differences affect drug response, does not explain all observed heritable variance in drug response. Epigenetic mechanisms, such as DNA methylation, and histone acetylation may account for some of the unexplained variances. Epigenetic mechanisms modulate gene expression and can be suitable drug targets and can impact the action of nonepigenetic drugs. Pharmacoepigenetics is the field that studies the relationship between epigenetic variability and drug response. Much of this research focuses on compounds targeting epigenetic mechanisms, called epigenetic drugs, which are used to treat cancers, immune disorders, and other diseases. Several studies also suggest an epigenetic role in classical drug response; however, we know little ab","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-08T12:18:17.394Z","creation":"2026-04-08T02:32:21.708Z"},"accession":"S-EPMC10406571","cross_references":{"pubmed":["37560024"],"doi":["10.1017/pcm.2023.6"]}}