biostudies-literatureKang DNCATS NIH HHSNIH HHS504https://www.ebi.ac.uk/biostudies/studies/S-EPMC10408090biostudies-literatureUnknown24(1)<h4>Objectives</h4>To compare hospitals that did and did not participate in clinical trials evaluating potential inpatient COVID-19 therapeutics.<h4>Methods</h4>We conducted a cross-sectional study of hospitals participating in trials that were registered on clinicaltrials.gov between April and August 2020. Using the 2019 RAND Hospital Dataset and 2019 American Community Survey, we used logistic regression modeling to compare hospital-level traits including demographic features between trial and non-trial hospitals.<h4>Results</h4>We included 488 hospitals that were participating in 298 interventional trials and 4232 non-participating hospitals. After controlling for demographic and other hospital traits, we found that teaching status (OR 2.11, 95% CI 1.52-2.95), higher patient acuity (OR TrialsDo hospitals that participate in COVID-19 research differ from non-trial hospitals? A cross-sectional study of US hospitals.PMC10408090P30AG021684UL1 TR001881ULL1TR001881Kang DHuang CXNorris KCVijayan TYuen ADfalseDo hospitals that participate in COVID-19 research differ from non-trial hospitals? A cross-sectional study of US hospitals.<h4>Objectives</h4>To compare hospitals that did and did not participate in clinical trials evaluating potential inpatient COVID-19 therapeutics.<h4>Methods</h4>We conducted a cross-sectional study of hospitals participating in trials that were registered on clinicaltrials.gov between April and August 2020. Using the 2019 RAND Hospital Dataset and 2019 American Community Survey, we used logistic regression modeling to compare hospital-level traits including demographic features between trial and non-trial hospitals.<h4>Results</h4>We included 488 hospitals that were participating in 298 interventional trials and 4232 non-participating hospitals. After controlling for demographic and other hospital traits, we found that teaching status (OR 2.11, 95% CI 1.52-2.95), higher patient acuity (OR 2023-01-01T00:00:00Z2023 Aug2025-04-04T03:06:35.099Z2024-12-04T03:20:18.204ZS-EPMC104080903755066210.1186/s13063-023-07450-6