{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Becerra-Artiles A"],"funding":["NCATS NIH HHS","Cardiovascular Medical Research and Education Fund","NIH/NCATS","NIH/NIAID","NIH HHS"],"pagination":["e1011032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10409285"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(7)"],"pubmed_abstract":["Seasonal \"common-cold\" human coronaviruses are widely spread throughout the world and are mainly associated with mild upper respiratory tract infections. The emergence of highly pathogenic coronaviruses MERS-CoV, SARS-CoV, and most recently SARS-CoV-2 has prompted increased attention to coronavirus biology and immunopathology, but the T-cell response to seasonal coronaviruses remains largely uncharacterized. Here we report the repertoire of viral peptides that are naturally processed and presented upon infection of a model cell line with seasonal coronavirus OC43. We identified MHC-bound peptides derived from each of the viral structural proteins (spike, nucleoprotein, hemagglutinin-esterase, membrane, and envelope) as well as non-structural proteins nsp3, nsp5, nsp6, and nsp12. Eighty MHC"],"journal":["PLoS pathogens"],"pubmed_title":["Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2."],"pmcid":["PMC10409285"],"funding_grant_id":["UL1 TR001453","R01-AI13798","S10 OD023438","S10 OD034358","UL1-TR001453"],"pubmed_authors":["Nanaware PP","Calvo-Calle JM","Muneeruddin K","Weaver GC","Stern LJ","Shaffer SA","Becerra-Artiles A"],"additional_accession":[]},"is_claimable":false,"name":"Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2.","description":"Seasonal \"common-cold\" human coronaviruses are widely spread throughout the world and are mainly associated with mild upper respiratory tract infections. The emergence of highly pathogenic coronaviruses MERS-CoV, SARS-CoV, and most recently SARS-CoV-2 has prompted increased attention to coronavirus biology and immunopathology, but the T-cell response to seasonal coronaviruses remains largely uncharacterized. Here we report the repertoire of viral peptides that are naturally processed and presented upon infection of a model cell line with seasonal coronavirus OC43. We identified MHC-bound peptides derived from each of the viral structural proteins (spike, nucleoprotein, hemagglutinin-esterase, membrane, and envelope) as well as non-structural proteins nsp3, nsp5, nsp6, and nsp12. Eighty MHC","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-07-07T03:09:38.773Z","creation":"2025-04-05T15:47:15.95Z"},"accession":"S-EPMC10409285","cross_references":{"pubmed":["37498934"],"doi":["10.1371/journal.ppat.1011032"]}}