{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["the National Natural Science Foundation of China"],"pagination":["735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10410993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>The centromere protein O (CENPO) is an important member of the centromere protein family. However, the role of CENPO in pan-cancer and immune infiltration has not been reported. Here, we investigated the role of CENPO in pan-cancer and further validated its role in lung adenocarcinoma (LUAD) by in vitro experiments.<h4>Method</h4>The UCSC Xena database and The Cancer Genome Atlas (TCGA)-LUAD data were used to assess the expression levels of CENPO. The potential value of CENPO as a diagnostic and prognostic biomarker for pan-cancer was evaluated using TCGA data and the GEPIA database. The -expression profiles of LUAD patients and the corresponding clinical data were downloaded for correlation analysis. The role of CENPO in immune infiltration was investigated using the UC"],"journal":["BMC cancer"],"pubmed_title":["Prognostic and immune infiltrative biomarkers of CENPO in pan-cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis."],"pmcid":["PMC10410993"],"funding_grant_id":["81560380"],"pubmed_authors":["Li H","Li Y","Tian L","Lv F","Fan Z","Li F","Ye D","Chen Y","Wang Y","Shen W"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic and immune infiltrative biomarkers of CENPO in pan-cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis.","description":"<h4>Background</h4>The centromere protein O (CENPO) is an important member of the centromere protein family. However, the role of CENPO in pan-cancer and immune infiltration has not been reported. Here, we investigated the role of CENPO in pan-cancer and further validated its role in lung adenocarcinoma (LUAD) by in vitro experiments.<h4>Method</h4>The UCSC Xena database and The Cancer Genome Atlas (TCGA)-LUAD data were used to assess the expression levels of CENPO. The potential value of CENPO as a diagnostic and prognostic biomarker for pan-cancer was evaluated using TCGA data and the GEPIA database. The -expression profiles of LUAD patients and the corresponding clinical data were downloaded for correlation analysis. The role of CENPO in immune infiltration was investigated using the UC","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-07T04:31:14.435Z","creation":"2024-11-15T17:14:24.855Z"},"accession":"S-EPMC10410993","cross_references":{"pubmed":["37558987"],"doi":["10.1186/s12885-023-11233-2"]}}