{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McPherson JE"],"funding":["NIA NIH HHS","National Institute of Health","NIGMS NIH HHS"],"pagination":["iyad106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10411577"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["224(4)"],"pubmed_abstract":["The chromatin of animal cells contains two types of histones: canonical histones that are expressed during S phase of the cell cycle to package the newly replicated genome, and variant histones with specialized functions that are expressed throughout the cell cycle and in non-proliferating cells. Determining whether and how canonical and variant histones cooperate to regulate genome function is integral to understanding how chromatin-based processes affect normal and pathological development. Here, we demonstrate that variant histone H3.3 is essential for Drosophila development only when canonical histone gene copy number is reduced, suggesting that coordination between canonical H3.2 and variant H3.3 expression is necessary to provide sufficient H3 protein for normal genome function. To i"],"journal":["Genetics"],"pubmed_title":["Reduced histone gene copy number disrupts Drosophila Polycomb function."],"pmcid":["PMC10411577"],"funding_grant_id":["NIGMS T32GM007092","NIGMS T32GM135128","F31 AG079632","R35 GM136435","R35GM145258","R35GM136435","R35 GM145258","R35 GM128851","T32 GM007092","R35GM128851","T32 GM135128"],"pubmed_authors":["Duronio RJ","Matera AG","McKay DJ","Grossmann LC","Armstrong RL","Kwon E","McPherson JE","Salzler HR"],"additional_accession":[]},"is_claimable":false,"name":"Reduced histone gene copy number disrupts Drosophila Polycomb function.","description":"The chromatin of animal cells contains two types of histones: canonical histones that are expressed during S phase of the cell cycle to package the newly replicated genome, and variant histones with specialized functions that are expressed throughout the cell cycle and in non-proliferating cells. Determining whether and how canonical and variant histones cooperate to regulate genome function is integral to understanding how chromatin-based processes affect normal and pathological development. Here, we demonstrate that variant histone H3.3 is essential for Drosophila development only when canonical histone gene copy number is reduced, suggesting that coordination between canonical H3.2 and variant H3.3 expression is necessary to provide sufficient H3 protein for normal genome function. To i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-04-07T16:21:16.475Z","creation":"2025-06-27T03:05:19.092Z"},"accession":"S-EPMC10411577","cross_references":{"pubmed":["37279945"],"doi":["10.1093/genetics/iyad106"]}}