{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Loan JJM"],"funding":["National Institute for Health Research (NIHR)","National Institute for Health and Care Research"],"pagination":["e075187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10414059"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(8)"],"pubmed_abstract":["<h4>Introduction</h4>The top research priority for cavernoma, identified by a James Lind Alliance Priority setting partnership was 'Does treatment (with neurosurgery or stereotactic radiosurgery) or no treatment improve outcome for people diagnosed with a cavernoma?' This pilot randomised controlled trial (RCT) aims to determine the feasibility of answering this question in a main phase RCT.<h4>Methods and analysis</h4>We will perform a pilot phase, parallel group, pragmatic RCT involving approximately 60 children or adults with mental capacity, resident in the UK or Ireland, with an unresected symptomatic brain cavernoma. Participants will be randomised by web-based randomisation 1:1 to treatment with medical management and with surgery (neurosurgery or stereotactic radiosurgery) versus m"],"journal":["BMJ open"],"pubmed_title":["Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma - protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial."],"pmcid":["PMC10414059"],"funding_grant_id":["NIHR128694"],"pubmed_authors":["Buddha S","Chapas L","Brodbelt A","Kamaly-Asl I","Angelopoulou K","James G","Lo WB","Hodnett R","Taylor M","Taylor L","Sutton R","Ferguson L","Ram D","Forsyth L","Patel S","van Beijnum J","Vassallo G","Patel M","Tarantino S","Kitchen N","Asif H","Hall R","Howe J","Colombo F","Bailey L","Muirhead W","Williams S","Fitzpatrick T","Turner C","White P","Chari A","Ross N","Harris LS","White D","White E","Knight SR","Ghosh A","Papadopoulos M","Teo M","Wright OW","Uff C","Guilfoyle M","Kambafwile M","Doke T","Eltze C","Cawley K","Marsden T","Tluchowska K","Marsden M","Wiggins A","Brydon H","Hancox R","Islam MM","Ruiz W","Agarwal S","Dore R","Parker L","Cromie TL","Sokol D","Goff E","Chaudhari K","Hill CS","Sharma P","Mallucci C","Teasdale J","Hennessy K","Cahill V","Clarkson E","Lewis S","Bacon A","Digpal R","Cahill J","Mukerji N","O'Malley L","McAleer D","Loan J","Tisdall M","Raha O","Harkness K","Atkinson B","Fawcett M","Anderson T","Irvine J","Anyog D","Muir F","Coakley M","Kamara C","Grover P","Keeping R","Salman RA","Stoddart A","Tajsic T","Borislavova B","Giannakaki V","Woodfield J","Walch A","Edwards RJ","Banaras A","Phillips N","Kearney S","Pennington R","McAndrew J","Dymond S","Vindlacheruvu R","Worner R","Mallick A","Reid J","McDarby A","Clatworthy P","Marimon R","Harris L","Anderson I","Bosetta E","Helmy A","Hudson C","Leach P","Hunter S","Shah R","Hughes T","Walsh D","Stewart J","Majeed S","Holland S","Goh ET","Beijnum JV","Israni A","Edwards R","Ponce I","Gurusinghe N","Wroe Wright O","Auyeung CK","Davies S","Slater V","Bjornson A","Kennion O","Welch B","Preston J","Hall PS","Cavernomas A Randomised Effectiveness (CARE) pilot trial collaborators","Chavredakis E","Kinsella E","Lee J","Fouyas I","McLaughlan D","Hennigan D","Neilson AR","Makwana M","Visagan R","Gardner J","Gunning B","Danciut M","Kadhim A","Brown A","MacDonald M","Rossdeutsch A","Jennings F","Caldwell K","Prasad M","Bhatt P","Hutchinson PJ","Brown D","Bohnacker N","Raffalli H","Bullen A","Richards E","Stephens D","Ganesan V","Brooks D","Nolasco J","Risbridger S","Stephen J","Farah JO","Spickett-Jones F","Makawa L","Roman M","Hamina I","Blesson D","Kaliaperumal C","Brennan P","Bates M","Loan JJM","Broomes N","Wade J","Webster C","Radatz M","Mayor I","Coskuner S","Mayor S","Coy K","Illingworth S","Whitehouse A","Stoneley C","Chambers C","Cope A","Bulters D","Wildman J","Hamandi K","Nair R","Sikaonga M","Mohamed S","Cirstea E","Raza-Knight S","Tshuma S","Papadopoulos MC","MacRaild A","Williamson J","Raj S","Glover S","Tahir Z","Holsgrove D","Ushewokunze S","Hayton T","Smith K","Ali S","Campbell C","Tucker L","Sokratous G","Al-Shahi Salman R","Bhate S"],"additional_accession":[]},"is_claimable":false,"name":"Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma - protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial.","description":"<h4>Introduction</h4>The top research priority for cavernoma, identified by a James Lind Alliance Priority setting partnership was 'Does treatment (with neurosurgery or stereotactic radiosurgery) or no treatment improve outcome for people diagnosed with a cavernoma?' This pilot randomised controlled trial (RCT) aims to determine the feasibility of answering this question in a main phase RCT.<h4>Methods and analysis</h4>We will perform a pilot phase, parallel group, pragmatic RCT involving approximately 60 children or adults with mental capacity, resident in the UK or Ireland, with an unresected symptomatic brain cavernoma. Participants will be randomised by web-based randomisation 1:1 to treatment with medical management and with surgery (neurosurgery or stereotactic radiosurgery) versus m","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T13:52:33.247Z","creation":"2025-02-19T03:56:37.751Z"},"accession":"S-EPMC10414059","cross_references":{"pubmed":["37558454"],"doi":["10.1136/bmjopen-2023-075187"]}}