{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yin Z"],"funding":["State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund","National Natural Science Foundation of China","Youth Science and technology top talent Program","Xinjiang Uygur Autonomous Region science and technology support project"],"pagination":["e0286358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10414599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(8)"],"pubmed_abstract":["Brucellosis is a common zoonosis, which is caused by Brucella infection, and Brucella often infects livestock, leading to abortion and infertility. At present, human brucellosis remains one of the major public health problems in China. According to previous research, most areas in northwest China, including Xinjiang, Tibet, and other regions, are severely affected by Brucella. Although there are vaccines against animal Brucellosis, the effect is often poor. In addition, there is no corresponding vaccine for human Brucellosis infection. Therefore, a new strategy for early prevention and treatment of Brucella is needed. A multi-epitope vaccine should be developed. In this study, we identified the antigenic epitopes of the Brucella type IV secretion system VirB8 and Virb10 using an immunoinfo"],"journal":["PloS one"],"pubmed_title":["Design of multi-epitope vaccine candidate against Brucella type IV secretion system (T4SS)."],"pmcid":["PMC10414599"],"funding_grant_id":["No.81860375","SKL-HIDCA 2021-JH11","No. 81860352","2022TSYCCX0112","2022E02061","No.81560322"],"pubmed_authors":["Niu C","Zhang F","Yu M","He Y","Xie X","Haimiti G","Guo W","Shi J","Ding J","Li M","Yin Z"],"additional_accession":[]},"is_claimable":false,"name":"Design of multi-epitope vaccine candidate against Brucella type IV secretion system (T4SS).","description":"Brucellosis is a common zoonosis, which is caused by Brucella infection, and Brucella often infects livestock, leading to abortion and infertility. At present, human brucellosis remains one of the major public health problems in China. According to previous research, most areas in northwest China, including Xinjiang, Tibet, and other regions, are severely affected by Brucella. Although there are vaccines against animal Brucellosis, the effect is often poor. In addition, there is no corresponding vaccine for human Brucellosis infection. Therefore, a new strategy for early prevention and treatment of Brucella is needed. A multi-epitope vaccine should be developed. In this study, we identified the antigenic epitopes of the Brucella type IV secretion system VirB8 and Virb10 using an immunoinfo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T06:34:40.509Z","creation":"2025-04-06T11:55:04.191Z"},"accession":"S-EPMC10414599","cross_references":{"pubmed":["37561685"],"doi":["10.1371/journal.pone.0286358"]}}