{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shreiber ST"],"funding":["Division of Chemistry","Merck KGaA","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["8542-8546"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10414767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(46)"],"pubmed_abstract":["An aryl disulfide mediated C-F bond activation of the trifluoromethyl group to generate valuable <i>gem-</i>difluoroalkylindoles is described. This method relies on readily available commodity reagents under mild reaction conditions and represents the first transition-metal-free redox-neutral C-F bond activation strategy. The reaction employs various substituted indoles and α-fluoro-substituted esters. Further, this mode of C-F activation was also amenable to the activation of trifluoromethylated arenes for the preparation of <i>bis</i>-benzylic <i>gem</i>-difluoromethylenes between indole and arene substructures, providing access to a unique chemical space."],"journal":["Organic letters"],"pubmed_title":["Visible-Light-Induced C-F Bond Activation for the Difluoroalkylation of Indoles."],"pmcid":["PMC10414767"],"funding_grant_id":["3R01GM087605-06S1","R01 GM087605","NSF CHE-1827457","RG2020","R01 GM118510","R35 GM131680","R35 GM 131680","3R01GM118510-03S1"],"pubmed_authors":["Granados A","Campbell MW","Patel S","Molander GA","Shreiber ST","Matsuo B","Majhi J"],"additional_accession":[]},"is_claimable":false,"name":"Visible-Light-Induced C-F Bond Activation for the Difluoroalkylation of Indoles.","description":"An aryl disulfide mediated C-F bond activation of the trifluoromethyl group to generate valuable <i>gem-</i>difluoroalkylindoles is described. This method relies on readily available commodity reagents under mild reaction conditions and represents the first transition-metal-free redox-neutral C-F bond activation strategy. The reaction employs various substituted indoles and α-fluoro-substituted esters. Further, this mode of C-F activation was also amenable to the activation of trifluoromethylated arenes for the preparation of <i>bis</i>-benzylic <i>gem</i>-difluoromethylenes between indole and arene substructures, providing access to a unique chemical space.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T14:30:13.575Z","creation":"2025-04-04T14:30:13.575Z"},"accession":"S-EPMC10414767","cross_references":{"pubmed":["36373860"],"doi":["10.1021/acs.orglett.2c03549"]}}