biostudies-literatureUnknown24(15)Loveland PMYugilbar FoundationNational Health and Medical Research Council (Australia)Inflammatory mechanisms are increasingly recognized as important contributors to the pathogenesis of neurodegenerative diseases, including Lewy body dementia (LBD). Our objectives were to, firstly, review inflammation investigation methods in LBD (dementia with Lewy bodies and Parkinson's disease dementia) and, secondly, identify alterations in inflammatory signals in LBD compared to people without neurodegenerative disease and other neurodegenerative diseases. A systematic scoping review was performed by searching major electronic databases (MEDLINE, Embase, Web of Science, and PSYCHInfo) to identify relevant human studies. Of the 2509 results screened, 80 studies were included. Thirty-six studies analyzed postmortem brain tissue, and 44 investigated living subjects with cerebrospinal fluInternational journal of molecular sciences12116https://www.ebi.ac.uk/biostudies/studies/S-EPMC10418754biostudies-literatureInvestigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.PMC10418754Churilov LLoveland PMYassi NWatson RYu JJfalseInvestigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.Inflammatory mechanisms are increasingly recognized as important contributors to the pathogenesis of neurodegenerative diseases, including Lewy body dementia (LBD). Our objectives were to, firstly, review inflammation investigation methods in LBD (dementia with Lewy bodies and Parkinson's disease dementia) and, secondly, identify alterations in inflammatory signals in LBD compared to people without neurodegenerative disease and other neurodegenerative diseases. A systematic scoping review was performed by searching major electronic databases (MEDLINE, Embase, Web of Science, and PSYCHInfo) to identify relevant human studies. Of the 2509 results screened, 80 studies were included. Thirty-six studies analyzed postmortem brain tissue, and 44 investigated living subjects with cerebrospinal flu2023-01-01T00:00:00Z2023 Jul2026-04-07T13:31:29.597Z2025-02-19T00:38:54.989ZS-EPMC104187543756949110.3390/ijms241512116