{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sabo MC"],"funding":["National Institute of Allergy and Infectious Diseases","NICHD NIH HHS","NIAID NIH HHS","University of Washington Center for AIDS Research","National Health and Medical Research Council","Wellcome Trust","National Institute of Child Health and Human Development"],"pagination":["343-352"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10420404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["228(3)"],"pubmed_abstract":["<h4>Background</h4>The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and MUC5AC are associated with Mycobacterium tuberculosis outcomes.<h4>Methods</h4>Independent SNPs in MUC5B and MUC5AC (genotyped by Illumina HumanOmniExpress array) were assessed for associations with tumor necrosis factor (TNF) concentrations (measured by immunoassay) in cerebral spinal fluid (CSF) from tuberculous meningitis (TBM) patients. SNPs associated with CSF TNF concentrations were carried forward for analyses of pulmonary and meningeal tuberculosis susceptibility and TBM mortality.<h4>Results</h4>MUC5AC SNP rs28737416 T allele was associated with lower CSF concentrations of TNF (P = 1.8 × 10-8) and IFN-γ (P = 2.3 × 10-6). In an additive genetic model, rs2873"],"journal":["The Journal of infectious diseases"],"pubmed_title":["MUC5AC Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid Cytokine Responses and Mortality."],"pmcid":["PMC10420404"],"funding_grant_id":["P30 AI027757","R01 AI136921","K23HD100221","R21 AI165961","K23 HD100221","K08 AI102971","P01 AI132130","APP1056689","106680/B/14/Z","P30 AI168034","1P30AI168034-01","206724/Z/17/Z","R01 AI145781","AI027757","L30 AI091018"],"pubmed_authors":["Bang ND","Thwaites GE","Kumar V","Thuong NTT","van Laarhoven A","Chang X","Shaporifar S","Nghia HDT","Ardiansyah E","Tram TTB","Li Z","van Crevel R","Heemskerk D","Sabo MC","Hai HT","Shah JA","Dian S","Khor CC","Ganiem AR","Dunstan SJ","Hibberd M"],"additional_accession":[]},"is_claimable":false,"name":"MUC5AC Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid Cytokine Responses and Mortality.","description":"<h4>Background</h4>The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and MUC5AC are associated with Mycobacterium tuberculosis outcomes.<h4>Methods</h4>Independent SNPs in MUC5B and MUC5AC (genotyped by Illumina HumanOmniExpress array) were assessed for associations with tumor necrosis factor (TNF) concentrations (measured by immunoassay) in cerebral spinal fluid (CSF) from tuberculous meningitis (TBM) patients. SNPs associated with CSF TNF concentrations were carried forward for analyses of pulmonary and meningeal tuberculosis susceptibility and TBM mortality.<h4>Results</h4>MUC5AC SNP rs28737416 T allele was associated with lower CSF concentrations of TNF (P = 1.8 × 10-8) and IFN-γ (P = 2.3 × 10-6). In an additive genetic model, rs2873","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-04-13T03:20:15.062Z","creation":"2025-04-04T07:49:00.754Z"},"accession":"S-EPMC10420404","cross_references":{"pubmed":["36823694"],"doi":["10.1093/infdis/jiad050"]}}