{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Aguilar D"],"pubmed_abstract":["The concept of \"one-airway-one-disease\", coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by distinct pathways. In this MeDALL (Mechanisms of the Development of Allergy) study, we leveraged the information of the human interactome to distinguish the molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis alone and rhinitis in multimorbidity with asthma. We observed significant differences in the topology of the interactomes and in the pathways associated to each phenotype. In rhinitis alone, identified pathways included cell cycle, cytokine signalling, developmental biology, immune system, metabolism of proteins and signal transduction."],"journal":["Scientific reports"],"pagination":["13125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10423213"],"repository":["biostudies-literature"],"pubmed_title":["Distinction between rhinitis alone and rhinitis with asthma using interactomics."],"pmcid":["PMC10423213"],"pubmed_authors":["Celedon JC","Anto JM","Lemonnier N","Melen E","Aguilar D","Gruzieva O","Koppelman GH","Guerra S","Bustamante M","Keil T","Bousquet J"],"additional_accession":[]},"is_claimable":false,"name":"Distinction between rhinitis alone and rhinitis with asthma using interactomics.","description":"The concept of \"one-airway-one-disease\", coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by distinct pathways. In this MeDALL (Mechanisms of the Development of Allergy) study, we leveraged the information of the human interactome to distinguish the molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis alone and rhinitis in multimorbidity with asthma. We observed significant differences in the topology of the interactomes and in the pathways associated to each phenotype. In rhinitis alone, identified pathways included cell cycle, cytokine signalling, developmental biology, immune system, metabolism of proteins and signal transduction.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T12:35:30.449Z","creation":"2025-04-05T12:35:30.449Z"},"accession":"S-EPMC10423213","cross_references":{"pubmed":["37573373"],"doi":["10.1038/s41598-023-39987-6"]}}