{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(1)"],"submitter":["Yang B"],"pubmed_abstract":["<i>Alkbh5</i> is one of the primary demethylases responsible for reversing N6-methyladenosine (m<sup>6</sup>A) modifications on mRNAs, and it plays a crucial role in many physiological and pathological processes. Previous studies have shown that <i>Alkbh5</i> is required for maintaining the function of leukemia stem cells but is dispensable for normal hematopoiesis. In this study, we found that <i>Alkbh5</i> deletion led to a moderate increase in the number of multiple progenitor cell populations while compromising the long-term self-renewal capacity of hematopoietic stem cells (HSCs). Here, we used RNA-seq and m<sup>6</sup>A-seq strategies to explore the underlying molecular mechanism. At the molecular level, <i>Alkbh5</i> may regulate hematopoiesis by reducing m<sup>6</sup>A modification"],"journal":["Open medicine (Warsaw, Poland)"],"pagination":["20230766"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10426271"],"repository":["biostudies-literature"],"pubmed_title":["<i>Alkbh5</i> plays indispensable roles in maintaining self-renewal of hematopoietic stem cells."],"pmcid":["PMC10426271"],"pubmed_authors":["Liu Y","Liu Z","Li Z","Zou L","Chen Z","Zhou C","Kuang M","Yang B","Xiao F","Shu Y","Liu S"],"additional_accession":[]},"is_claimable":false,"name":"<i>Alkbh5</i> plays indispensable roles in maintaining self-renewal of hematopoietic stem cells.","description":"<i>Alkbh5</i> is one of the primary demethylases responsible for reversing N6-methyladenosine (m<sup>6</sup>A) modifications on mRNAs, and it plays a crucial role in many physiological and pathological processes. Previous studies have shown that <i>Alkbh5</i> is required for maintaining the function of leukemia stem cells but is dispensable for normal hematopoiesis. In this study, we found that <i>Alkbh5</i> deletion led to a moderate increase in the number of multiple progenitor cell populations while compromising the long-term self-renewal capacity of hematopoietic stem cells (HSCs). Here, we used RNA-seq and m<sup>6</sup>A-seq strategies to explore the underlying molecular mechanism. At the molecular level, <i>Alkbh5</i> may regulate hematopoiesis by reducing m<sup>6</sup>A modification","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-19T06:49:38.821Z","creation":"2025-04-19T06:49:38.821Z"},"accession":"S-EPMC10426271","cross_references":{"pubmed":["37588656"],"doi":["10.1515/med-2023-0766"]}}