{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Durkin J"],"funding":["Burroughs Wellcome Fund","Alfred P Sloan Foundation","NHLBI NIH HHS","NIMH NIH HHS","U.S. Department of Defense","March of Dimes Foundation","NINDS NIH HHS","National Institutes of Health","Hartwell Foundation"],"pagination":["100101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10428071"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including <i>Drosophila</i>, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene <i>Neurofibromin 1</i> (<i>Nf1</i>) in sleep during numerous developmental periods. Mutations in <i>Neurofibromin 1</i> (<i>Nf1</i>) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that <i>Nf1</i> acts to regulate "],"journal":["Neurobiology of sleep and circadian rhythms"],"pubmed_title":["<i>Neurofibromin 1</i> regulates early developmental sleep in <i>Drosophila</i>."],"pmcid":["PMC10428071"],"funding_grant_id":["DP2 NS111996","T32 MH014654","F32NS117785","T32HL007713","T32 HL007713","T32MH014654","DP2NS111996","W81XWH-20-1-0206","W81XWH-16-1-0220","F32 NS117785"],"pubmed_authors":["Tang SH","Belfer SJ","Poe AR","Kayser MS","Rodriguez A","Durkin J","Walker JA"],"additional_accession":[]},"is_claimable":false,"name":"<i>Neurofibromin 1</i> regulates early developmental sleep in <i>Drosophila</i>.","description":"Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including <i>Drosophila</i>, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene <i>Neurofibromin 1</i> (<i>Nf1</i>) in sleep during numerous developmental periods. Mutations in <i>Neurofibromin 1</i> (<i>Nf1</i>) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that <i>Nf1</i> acts to regulate ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-04T08:03:49.273Z","creation":"2025-04-21T22:09:26.625Z"},"accession":"S-EPMC10428071","cross_references":{"pubmed":["37593040"],"doi":["10.1016/j.nbscr.2023.100101"]}}