biostudies-literatureUnknown14(32)Pearcy ACA new sequential metalation strategy that enables the assembly of a new more robust reduced symmetry heterobimetallic [PdPtL₄]⁴⁺ cage C is reported. By exploiting a low-symmetry ditopic ligand (L) that features imidazole and pyridine donor units we were able to selectively form a [Pt(L)₄]²⁺ "open-cage" complex. When this was treated with Pd(ii) ions the cage C assembled. ¹H and DOSY nuclear magnetic resonance (NMR) spectroscopy and electrospray ionisation mass spectrometry (ESIMS) data were consistent with the quantitative formation of the cage and the heterobimetallic structure was confirmed by single crystal X-ray crystallography. The cage C was shown to bind anionic guest molecules. NMR studies suggested that these guests interactedChemical science8615-8623https://www.ebi.ac.uk/biostudies/studies/S-EPMC10430685biostudies-literatureExploiting reduced-symmetry ligands with pyridyl and imidazole donors to construct a second-generation stimuli-responsive heterobimetallic [PdPtL₄]⁴⁺ cage.PMC10430685Hartinger CGLisboa LSPreston DPage NBLawrence TCrowley JDPearcy ACWright LJfalseExploiting reduced-symmetry ligands with pyridyl and imidazole donors to construct a second-generation stimuli-responsive heterobimetallic [PdPtL₄]⁴⁺ cage.A new sequential metalation strategy that enables the assembly of a new more robust reduced symmetry heterobimetallic [PdPtL₄]⁴⁺ cage C is reported. By exploiting a low-symmetry ditopic ligand (L) that features imidazole and pyridine donor units we were able to selectively form a [Pt(L)₄]²⁺ "open-cage" complex. When this was treated with Pd(ii) ions the cage C assembled. ¹H and DOSY nuclear magnetic resonance (NMR) spectroscopy and electrospray ionisation mass spectrometry (ESIMS) data were consistent with the quantitative formation of the cage and the heterobimetallic structure was confirmed by single crystal X-ray crystallography. The cage C was shown to bind anionic guest molecules. NMR studies suggested that these guests interacted2023-01-01T00:00:00Z2023 Aug2025-04-04T20:04:29.096Z2025-04-04T20:04:29.096ZS-EPMC104306853759299610.1039/d3sc01354e