biostudies-literatureChoi SJRural Development Administration29770-29778https://www.ebi.ac.uk/biostudies/studies/S-EPMC10433477biostudies-literatureUnknown8(32)Ethylene is a gaseous hydrocarbon molecule known as a plant hormone that promotes fruit ripening and senescence. Efficiently controlling ethylene is a central key to maintaining the quality of agricultural products. The current study uncovered a synthetic method for 1-(2,2-dimethylpropyl)-cyclopropene (1-DCP) as a cyclopropene derivative to inhibit ethylene action in fruit ripening and senescence. We synthesized 1-DCP using α-diisobutylene through a two-step process, including allylic chlorination by hypochlorite and HCl, followed by α-elimination of the allylic chloride using a strong base, lithium diethylamide. GC-MS and NMR analyses demonstrated that 1-DCP was synthesized efficiently with 35% yield and 95% purity. When treated as an aqueous emulsion on plants, including persimmon and baACS omegaSynthesis of 1-(2,2-Dimethylpropyl)-Cyclopropene (1-DCP) as an Ethylene Antagonist.PMC10433477PJ01696801Jahng WJChoi SJAhn GHLee KHfalseSynthesis of 1-(2,2-Dimethylpropyl)-Cyclopropene (1-DCP) as an Ethylene Antagonist.Ethylene is a gaseous hydrocarbon molecule known as a plant hormone that promotes fruit ripening and senescence. Efficiently controlling ethylene is a central key to maintaining the quality of agricultural products. The current study uncovered a synthetic method for 1-(2,2-dimethylpropyl)-cyclopropene (1-DCP) as a cyclopropene derivative to inhibit ethylene action in fruit ripening and senescence. We synthesized 1-DCP using α-diisobutylene through a two-step process, including allylic chlorination by hypochlorite and HCl, followed by α-elimination of the allylic chloride using a strong base, lithium diethylamide. GC-MS and NMR analyses demonstrated that 1-DCP was synthesized efficiently with 35% yield and 95% purity. When treated as an aqueous emulsion on plants, including persimmon and ba2023-01-01T00:00:00Z2023 Aug2026-05-29T08:03:13.408Z2024-11-07T09:54:39.398ZS-EPMC104334773759992610.1021/acsomega.3c04220