biostudies-literatureYoung LWEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNCATS NIH HHSNational Institutes of HealthNIH HHS2326-2337https://www.ebi.ac.uk/biostudies/studies/S-EPMC10433732biostudies-literatureUnknown388(25)<h4>Background</h4>Although clinicians have traditionally used the Finnegan Neonatal Abstinence Scoring Tool to assess the severity of neonatal opioid withdrawal, a newer function-based approach - the Eat, Sleep, Console care approach - is increasing in use. Whether the new approach can safely reduce the time until infants are medically ready for discharge when it is applied broadly across diverse sites is unknown.<h4>Methods</h4>In this cluster-randomized, controlled trial at 26 U.S. hospitals, we enrolled infants with neonatal opioid withdrawal syndrome who had been born at 36 weeks' gestation or more. At a randomly assigned time, hospitals transitioned from usual care that used the Finnegan tool to the Eat, Sleep, Console approach. During a 3-month transition period, staff members at eaThe New England journal of medicineEat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.PMC10433732UG1 HD068278U24OD0249571U24HD095254UG1 OD024958UG1 OD024959UG1 OD024943UG1 OD0249453U2COD023375UG1 OD024942UG1 HD027853U2C OD023375UG1 HD087226UG1 HD040492U10 HD036790U24 OD024957UG1 HD068244UG1 HD068263UG1 HD053109U01 HD036790UL1 TR001117U24 HD095254UG1 OD024947UG1 OD024948UG1 HD053089UG1 OD024954UG1 OD024955UG1 OD024956UG1 OD024950UG1 OD024953UG1 HD021364AkshathaMaxwell JRCrawford MMCrowley MHu ZHiggins RDHahn DWSmith PBHowell MPPhD ADWright TOunpraseuth SOunpraseuth STMerhar SLSimon AEReynolds AMMcAllister JMGreenberg RGRice WBraswell EFMcAlmon KRBremer AARoss JShaikh SKSnowden JNNewman SAkshatha ARiccio JDummula KACT NOW CollaborativeWeiner JLee JYWalsh MCWong Ramsey KPaul DADevlin LAYoung LWPuopolo KMWhite JRChrist LBrown JMs ZHPoindexter BBFung CMDas ATucker LTelang SfalseEat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.<h4>Background</h4>Although clinicians have traditionally used the Finnegan Neonatal Abstinence Scoring Tool to assess the severity of neonatal opioid withdrawal, a newer function-based approach - the Eat, Sleep, Console care approach - is increasing in use. Whether the new approach can safely reduce the time until infants are medically ready for discharge when it is applied broadly across diverse sites is unknown.<h4>Methods</h4>In this cluster-randomized, controlled trial at 26 U.S. hospitals, we enrolled infants with neonatal opioid withdrawal syndrome who had been born at 36 weeks' gestation or more. At a randomly assigned time, hospitals transitioned from usual care that used the Finnegan tool to the Eat, Sleep, Console approach. During a 3-month transition period, staff members at ea2023-01-01T00:00:00Z2023 Jun2026-05-28T13:02:27.355Z2025-04-06T16:28:33.892ZS-EPMC104337323712583110.1056/NEJMoa221447010.1056/nejmoa2214470