{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Ahmad S"],"pubmed_abstract":["Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse effects and enhance results. Making use of this multi-target approach, a series of naproxen-sulfa drug conjugates was designed and synthesized. The newly designed conjugates were confirmed by spectroscopic techniques like IR, <sup>1</sup>HNMR, <sup>13</sup>CNMR, and elemental analysis. The conjugates were screened for anti-inflammatory, urease, and cyclooxygenase-2 (COX-2) inhibition. Naproxen conjugated with sulfanilamide, sulfathiazole, and sulfaguanidine was found potent and showed a competitive mode of urease inhibition, with IC<sub>50</sub> (µM) values 6.69 ± 0.11, 5.82 ± 0.28, 5.06 ± 0.29, respectively. When compared to other screened conjugates, the n"],"journal":["Frontiers in chemistry"],"pagination":["1206380"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10434765"],"repository":["biostudies-literature"],"pubmed_title":["Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their <i>in silico</i> studies."],"pmcid":["PMC10434765"],"pubmed_authors":["Muddassar M","Ali I","Yousaf N","Imran M","Ahmad S","Abdul Qadir M","Zargar S","Wani TA","Ahmed M"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their <i>in silico</i> studies.","description":"Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse effects and enhance results. Making use of this multi-target approach, a series of naproxen-sulfa drug conjugates was designed and synthesized. The newly designed conjugates were confirmed by spectroscopic techniques like IR, <sup>1</sup>HNMR, <sup>13</sup>CNMR, and elemental analysis. The conjugates were screened for anti-inflammatory, urease, and cyclooxygenase-2 (COX-2) inhibition. Naproxen conjugated with sulfanilamide, sulfathiazole, and sulfaguanidine was found potent and showed a competitive mode of urease inhibition, with IC<sub>50</sub> (µM) values 6.69 ± 0.11, 5.82 ± 0.28, 5.06 ± 0.29, respectively. When compared to other screened conjugates, the n","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T13:11:36.597Z","creation":"2024-10-16T04:56:18.463Z"},"accession":"S-EPMC10434765","cross_references":{"pubmed":["37601915"],"doi":["10.3389/fchem.2023.1206380"]}}