biostudies-literatureUnknown18(8)Gu S<h4>Introduction and aims</h4>High intensity interval training (HIIT) is considered as an alternative exercise modality to moderate intensity continuous training (MICT) for heart failure (HF) patients. Yet a growing number of trials demonstrated inconsistent findings about the effectiveness of HIIT versus MICT until SMARTEX study and OptimEx-Clin study have made a consistent negative conclusion that HIIT was not superior to MICT. The aim of this study was to conduct a meta-analysis involving a subgroup analysis of total exercise time (TET) and disease categories of HF to investigate if TET could affect the superiority of HIIT when compared with MICT.<h4>Methods and results</h4>An electronic literature search of Pubmed, Embase, Cochrane Central Register of Controlled Trials and ClinicalTriaPloS onee0290362https://www.ebi.ac.uk/biostudies/studies/S-EPMC10434865biostudies-literatureEffects of high intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure: A systematic review and meta-analysis.PMC10434865Gu SWang DDu XGuo SYu YfalseEffects of high intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure: A systematic review and meta-analysis.<h4>Introduction and aims</h4>High intensity interval training (HIIT) is considered as an alternative exercise modality to moderate intensity continuous training (MICT) for heart failure (HF) patients. Yet a growing number of trials demonstrated inconsistent findings about the effectiveness of HIIT versus MICT until SMARTEX study and OptimEx-Clin study have made a consistent negative conclusion that HIIT was not superior to MICT. The aim of this study was to conduct a meta-analysis involving a subgroup analysis of total exercise time (TET) and disease categories of HF to investigate if TET could affect the superiority of HIIT when compared with MICT.<h4>Methods and results</h4>An electronic literature search of Pubmed, Embase, Cochrane Central Register of Controlled Trials and ClinicalTria2023-01-01T00:00:00Z20232025-04-05T12:35:33.234Z2025-04-05T12:35:33.234ZS-EPMC104348653759031210.1371/journal.pone.0290362