{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(3)"],"submitter":["Shohdy KS"],"pubmed_abstract":["The persistence and reactivity of CAR T cells were enhanced by adding co-stimulatory domains, which is the basis of currently approved CAR-T cell therapies. However, this comes at the expense of increasing toxicities from the strong cytokine release effect. This is the first report from anti-CD19 CAR-T cell therapy with a single activation domain to show a favourable safety profile and clinical efficacy with two patients who achieved durable responses up to 28 months in a cohort with heavily pretreated B cell malignancies."],"journal":["EJHaem"],"pagination":["882-885"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10435680"],"repository":["biostudies-literature"],"pubmed_title":["Evidence of clinical efficacy of a first generation CD19 CAR T cell in B cell malignancies."],"pmcid":["PMC10435680"],"pubmed_authors":["Chow S","Rothwell D","Kirillova N","Pillai M","Gilham D","Shohdy KS","Hawkins R","Guest R","Thistlethwaite F"],"additional_accession":[]},"is_claimable":false,"name":"Evidence of clinical efficacy of a first generation CD19 CAR T cell in B cell malignancies.","description":"The persistence and reactivity of CAR T cells were enhanced by adding co-stimulatory domains, which is the basis of currently approved CAR-T cell therapies. However, this comes at the expense of increasing toxicities from the strong cytokine release effect. This is the first report from anti-CD19 CAR-T cell therapy with a single activation domain to show a favourable safety profile and clinical efficacy with two patients who achieved durable responses up to 28 months in a cohort with heavily pretreated B cell malignancies.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-06-04T08:02:55.147Z","creation":"2025-04-05T15:56:08.396Z"},"accession":"S-EPMC10435680","cross_references":{"pubmed":["37601889"],"doi":["10.1002/jha2.731"]}}