{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["145(32)"],"submitter":["Badgurjar D"],"funding":["American Chemical Society Petroleum Research Fund"],"pubmed_abstract":["Charge-transfer events central to energy conversion and storage and molecular sensing occur at electrified interfaces. Synthetic control over the interface is traditionally accessed through electrode-specific covalent tethering of molecules. Covalent linkages inherently limit the scope and the potential stability window of molecularly tunable electrodes. Here, we report a synthetic strategy that is agnostic to the electrode's surface chemistry to molecularly define electrified interfaces. We append ferrocene redox reporters to amphiphiles, utilizing non-covalent electrostatic and van der Waals interactions to prepare a self-assembled layer stable over a 2.9 V range. The layer's voltammetric response and <i>in situ</i> infrared spectra mimic those reported for analogous covalently bound ferrocene. This design is electrode-orthogonal; layer self-assembly is reversible and independent of the underlying electrode material's surface chemistry. We demonstrate that the design can be utilized across a wide range of electrode material classes (transition metal, carbon, carbon composites) and morphologies (nanostructured, planar). Merging atomically precise organic synthesis of amphiphiles with <i>in situ</i> non-covalent self-assembly at polarized electrodes, our work sets the stage for predictive and non-fouling synthetic control over electrified interfaces."],"journal":["Journal of the American Chemical Society"],"pagination":["17734-17745"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10436282"],"repository":["biostudies-literature"],"pubmed_title":["Non-Covalent Interactions Mimic the Covalent: An Electrode-Orthogonal Self-Assembled Layer."],"pmcid":["PMC10436282"],"pubmed_authors":["Badgurjar D","Huynh M","Wuttig A","Masters B"],"additional_accession":[]},"is_claimable":false,"name":"Non-Covalent Interactions Mimic the Covalent: An Electrode-Orthogonal Self-Assembled Layer.","description":"Charge-transfer events central to energy conversion and storage and molecular sensing occur at electrified interfaces. Synthetic control over the interface is traditionally accessed through electrode-specific covalent tethering of molecules. Covalent linkages inherently limit the scope and the potential stability window of molecularly tunable electrodes. Here, we report a synthetic strategy that is agnostic to the electrode's surface chemistry to molecularly define electrified interfaces. We append ferrocene redox reporters to amphiphiles, utilizing non-covalent electrostatic and van der Waals interactions to prepare a self-assembled layer stable over a 2.9 V range. The layer's voltammetric response and <i>in situ</i> infrared spectra mimic those reported for analogous covalently bound ferrocene. This design is electrode-orthogonal; layer self-assembly is reversible and independent of the underlying electrode material's surface chemistry. We demonstrate that the design can be utilized across a wide range of electrode material classes (transition metal, carbon, carbon composites) and morphologies (nanostructured, planar). Merging atomically precise organic synthesis of amphiphiles with <i>in situ</i> non-covalent self-assembly at polarized electrodes, our work sets the stage for predictive and non-fouling synthetic control over electrified interfaces.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-21T22:10:18.971Z","creation":"2025-04-05T18:36:54.802Z"},"accession":"S-EPMC10436282","cross_references":{"pubmed":["37548952"],"doi":["10.1021/jacs.3c04387"]}}