{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Puasri P"],"pubmed_abstract":["<h4>Background</h4>Gnathostomiasis is an important zoonosis in tropical areas that is mainly caused by third-stage <i>Gnathostoma spinigerum</i> larvae (<i>G. spinigerum</i> L3).<h4>Objectives</h4>This study aimed to prove whether <i>G. spinigerum</i> L3 produces extracellular vesicles (EVs) and investigate human gene profiles related to the immune response against the larvae.<h4>Methods</h4>We created an immune cell model using normal human peripheral blood mononuclear cells (PBMCs) co-cultured with the larvae for 1 and 3 days, respectively. The PBMCs were harvested for transcriptome sequencing analysis. The EV ultrastructure was examined in the larvae and the cultured medium.<h4>Results</h4>Extracellular vesicle-like particles were observed under the larval teguments and in the pellets i"],"journal":["Frontiers in immunology"],"pagination":["1218965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10436992"],"repository":["biostudies-literature"],"pubmed_title":["Regulation of immune response against third-stage <i>Gnathostoma spinigerum</i> larvae by human genes."],"pmcid":["PMC10436992"],"pubmed_authors":["Reamtong O","Boonyuen U","Yoonuan T","Benjathummarak S","Dekumyoy P","Ampawong S","Puasri P","Dechkhajorn W","Maneerat Y"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of immune response against third-stage <i>Gnathostoma spinigerum</i> larvae by human genes.","description":"<h4>Background</h4>Gnathostomiasis is an important zoonosis in tropical areas that is mainly caused by third-stage <i>Gnathostoma spinigerum</i> larvae (<i>G. spinigerum</i> L3).<h4>Objectives</h4>This study aimed to prove whether <i>G. spinigerum</i> L3 produces extracellular vesicles (EVs) and investigate human gene profiles related to the immune response against the larvae.<h4>Methods</h4>We created an immune cell model using normal human peripheral blood mononuclear cells (PBMCs) co-cultured with the larvae for 1 and 3 days, respectively. The PBMCs were harvested for transcriptome sequencing analysis. The EV ultrastructure was examined in the larvae and the cultured medium.<h4>Results</h4>Extracellular vesicle-like particles were observed under the larval teguments and in the pellets i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-12T23:03:19.675Z","creation":"2025-04-06T17:48:27.803Z"},"accession":"S-EPMC10436992","cross_references":{"pubmed":["37600806"],"doi":["10.3389/fimmu.2023.1218965"]}}