biostudies-literatureLiu SWKey Research and Development Program of Jiangxi Provincethe Development Grant of Key Laboratory of Health Commission of Jiangxi ProvinceScience and Technology Program of Health Commission of Jiangxi Provincee0011540https://www.ebi.ac.uk/biostudies/studies/S-EPMC10437993biostudies-literatureUnknown17(8)<h4>Background</h4>Rodents are the predominant natural hosts of orthohantavirus and the source of human infection, hemorrhagic fever with renal syndrome (HFRS) caused by orthohantavirus is a severe public health problem in the Yichun region, Jiangxi Province, China. However, little information is known about the infection of orthohantavirus in humans and rodents, and the genetic characteristics of the epidemic orthohantavirus in the region.<h4>Methods</h4>The clinical data of HFRS cases in 2016-2021 was analyzed. Virus infection in rodents was analyzed by orthohantavirus antigen detection using immunofluorescent assay, and the species of orthohantaviruses in rodents and patients were identified by real-time RT-PCR and gene sequencing. The S and M segments of orthohantaviruses from rodents PLoS neglected tropical diseasesOrthohantavirus infections in humans and rodents in the Yichun region, China, from 2016 to 2021.PMC1043799320203BBG73055202211313Xiong YLiu SWZou LLiu XQXu GLi JXLong ZEfalseOrthohantavirus infections in humans and rodents in the Yichun region, China, from 2016 to 2021.<h4>Background</h4>Rodents are the predominant natural hosts of orthohantavirus and the source of human infection, hemorrhagic fever with renal syndrome (HFRS) caused by orthohantavirus is a severe public health problem in the Yichun region, Jiangxi Province, China. However, little information is known about the infection of orthohantavirus in humans and rodents, and the genetic characteristics of the epidemic orthohantavirus in the region.<h4>Methods</h4>The clinical data of HFRS cases in 2016-2021 was analyzed. Virus infection in rodents was analyzed by orthohantavirus antigen detection using immunofluorescent assay, and the species of orthohantaviruses in rodents and patients were identified by real-time RT-PCR and gene sequencing. The S and M segments of orthohantaviruses from rodents 2023-01-01T00:00:00Z2023 Aug2026-05-29T08:01:50.682Z2025-04-04T10:09:50.627ZS-EPMC104379933755267010.1371/journal.pntd.0011540