{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Komori S"],"funding":["MEXT | Japan Society for the Promotion of Science","Japan Agency for Medical Research and Development"],"pagination":["e2304943120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10440595"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(33)"],"pubmed_abstract":["Conventional dendritic cells (cDCs) are required for peripheral T cell homeostasis in lymphoid organs, but the molecular mechanism underlying this requirement has remained unclear. We here show that T cell-specific CD47-deficient (<i>Cd47</i><sup> ΔT</sup>) mice have a markedly reduced number of T cells in peripheral tissues. Direct interaction of CD47-deficient T cells with cDCs resulted in activation of the latter cells, which in turn induced necroptosis of the former cells. The deficiency and cell death of T cells in <i>Cd47</i><sup>  ΔT</sup> mice required expression of its receptor signal regulatory protein α on cDCs. The development of CD4<sup>+</sup> T helper cell-dependent contact hypersensitivity and inhibition of tumor growth by cytotoxic CD8<sup>+</sup> T cells were both markedl"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis."],"pmcid":["PMC10440595"],"funding_grant_id":["21H04807","21cm0106308h0006","22K15494","22K08504","22674074"],"pubmed_authors":["Nitta E","Afroj T","Kaneko Y","Respatika D","Endoh H","Saito Y","Iida-Norita R","Kotani T","Yoshida H","Komori S","Ohnishi H","Matozaki T","Oduori OS","Nitta R","Murata Y","Takai T","Nishimura T","Sugihara R"],"additional_accession":[]},"is_claimable":false,"name":"CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis.","description":"Conventional dendritic cells (cDCs) are required for peripheral T cell homeostasis in lymphoid organs, but the molecular mechanism underlying this requirement has remained unclear. We here show that T cell-specific CD47-deficient (<i>Cd47</i><sup> ΔT</sup>) mice have a markedly reduced number of T cells in peripheral tissues. Direct interaction of CD47-deficient T cells with cDCs resulted in activation of the latter cells, which in turn induced necroptosis of the former cells. The deficiency and cell death of T cells in <i>Cd47</i><sup>  ΔT</sup> mice required expression of its receptor signal regulatory protein α on cDCs. The development of CD4<sup>+</sup> T helper cell-dependent contact hypersensitivity and inhibition of tumor growth by cytotoxic CD8<sup>+</sup> T cells were both markedl","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-22T05:32:10.329Z","creation":"2025-04-05T21:23:40.945Z"},"accession":"S-EPMC10440595","cross_references":{"pubmed":["37549290"],"doi":["10.1073/pnas.2304943120"]}}