biostudies-literatureUnknown26(8)Li JXChronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, is influenced by genetic factors. The genetic signal rs10516526 in the glutathione S-transferase C-terminal domain containing (<i>GSTCD</i>) gene is a highly significant and reproducible signal associated with lung function and COPD on chromosome 4q24. In this study, comprehensive bioinformatics analyses and experimental verifications were detailly implemented to explore the regulation mechanism of rs10516526 and <i>GSTCD</i> in COPD. The results suggested that low expression of <i>GSTCD</i> was associated with COPD (p = 0.010). And C-Jun and CREB1 transcription factors were found to be essential for the regulation of <i>GSTCD</i> by rs80245547 and rs72673891. Moreover, rs80245547T and rs72673891G hadiScience107383https://www.ebi.ac.uk/biostudies/studies/S-EPMC10440715biostudies-literatureRemote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect <i>GSTCD</i> expression.PMC10440715Zhang XHYu LHuang XZZhang JDai LMMauki DHSun CFu WPLi JXZhong LZhang YPfalseRemote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect <i>GSTCD</i> expression.Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, is influenced by genetic factors. The genetic signal rs10516526 in the glutathione S-transferase C-terminal domain containing (<i>GSTCD</i>) gene is a highly significant and reproducible signal associated with lung function and COPD on chromosome 4q24. In this study, comprehensive bioinformatics analyses and experimental verifications were detailly implemented to explore the regulation mechanism of rs10516526 and <i>GSTCD</i> in COPD. The results suggested that low expression of <i>GSTCD</i> was associated with COPD (p = 0.010). And C-Jun and CREB1 transcription factors were found to be essential for the regulation of <i>GSTCD</i> by rs80245547 and rs72673891. Moreover, rs80245547T and rs72673891G had2023-01-01T00:00:00Z2023 Aug2026-05-28T15:25:19.802Z2024-10-18T11:00:35.23ZS-EPMC104407153760963810.1016/j.isci.2023.107383