biostudies-literatureUnknown39(5)Nakamae K<h4>Purpose</h4>To evaluate the early and long-term outcomes of left ventricular posterior wall plication for ischemic mitral regurgitation.<h4>Methods</h4>Patients with ischemic mitral regurgitation who underwent left ventricular posterior wall plication via right-sided left atriotomy at our institution between 2010 and 2020 were retrospectively reviewed. Cases with normal cardiac function, left ventricular end-systolic diameter < 50 mm, and left ventriculotomy approach were excluded.<h4>Results</h4>The mean follow-up period was 5.3 years [standard deviation (SD) = 3.5], with a maximum of 10 years. Among the 21 patients enrolled, 9 had New York Heart Association (NYHA) class ≥ III. Three patients required preoperative inotrope support, while two preoperative ventilator support. The mean left ventricular ejection fraction was 31.4% (SD: 8.6), and 16 patients had mitral regurgitation grade ≥ III. All patients underwent coronary artery bypass grafting and mitral annuloplasty. Concomitant surgeries included 11 chordae cutting and 3 tricuspid annuloplasties. One in-hospital death occurred due to sepsis. At the follow-up, echocardiographic data showed significant improvement in cardiac dilation and function and good control of mitral regurgitation. The serum brain natriuretic peptide level was significantly reduced, and 85% of patients improved to NYHA class I. Four deaths occurred later due to sudden, unknown causes. The 5- and 8-year survival rates were 60.2% and 46.8%, respectively, and the 5- and 8-year hospitalization rates due to heart failure were 14.9% and 21.3%, respectively.<h4>Conclusion</h4>The long-term outcomes of left ventricular posterior wall plication were satisfactory for controlling heart failure and improving survival rate and patient prognosis.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s12055-023-01527-2.Indian journal of thoracic and cardiovascular surgery462-470https://www.ebi.ac.uk/biostudies/studies/S-EPMC10442011biostudies-literatureLong-term outcomes of left ventricular posterior wall plication for ischemic mitral regurgitation.PMC10442011Ideta IOshitomi TSassa TTakaji KMurata HHirota MNakamae KUesugi HfalseLong-term outcomes of left ventricular posterior wall plication for ischemic mitral regurgitation.<h4>Purpose</h4>To evaluate the early and long-term outcomes of left ventricular posterior wall plication for ischemic mitral regurgitation.<h4>Methods</h4>Patients with ischemic mitral regurgitation who underwent left ventricular posterior wall plication via right-sided left atriotomy at our institution between 2010 and 2020 were retrospectively reviewed. Cases with normal cardiac function, left ventricular end-systolic diameter < 50 mm, and left ventriculotomy approach were excluded.<h4>Results</h4>The mean follow-up period was 5.3 years [standard deviation (SD) = 3.5], with a maximum of 10 years. Among the 21 patients enrolled, 9 had New York Heart Association (NYHA) class ≥ III. Three patients required preoperative inotrope support, while two preoperative ventilator support. The mean left ventricular ejection fraction was 31.4% (SD: 8.6), and 16 patients had mitral regurgitation grade ≥ III. All patients underwent coronary artery bypass grafting and mitral annuloplasty. Concomitant surgeries included 11 chordae cutting and 3 tricuspid annuloplasties. One in-hospital death occurred due to sepsis. At the follow-up, echocardiographic data showed significant improvement in cardiac dilation and function and good control of mitral regurgitation. The serum brain natriuretic peptide level was significantly reduced, and 85% of patients improved to NYHA class I. Four deaths occurred later due to sudden, unknown causes. The 5- and 8-year survival rates were 60.2% and 46.8%, respectively, and the 5- and 8-year hospitalization rates due to heart failure were 14.9% and 21.3%, respectively.<h4>Conclusion</h4>The long-term outcomes of left ventricular posterior wall plication were satisfactory for controlling heart failure and improving survival rate and patient prognosis.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s12055-023-01527-2.2023-01-01T00:00:00Z2023 Sep2026-04-08T01:28:04.368Z2025-04-06T16:46:49.249ZS-EPMC104420113760960910.1007/s12055-023-01527-2