{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(8)"],"submitter":["Cardinale V"],"pubmed_abstract":["This review aims to evaluate the current preclinical state of liver bioengineering, the clinical context for liver cell therapies, the cell sources, the delivery routes, and the results of clinical trials for end-stage liver disease. Different clinical settings, such as inborn errors of metabolism, acute liver failure, chronic liver disease, liver cirrhosis, and acute-on-chronic liver failure, as well as multiple cellular sources were analyzed; namely, hepatocytes, hepatic progenitor cells, biliary tree stem/progenitor cells, mesenchymal stromal cells, and macrophages. The highly heterogeneous clinical scenario of liver disease and the availability of multiple cellular sources endowed with different biological properties make this a multidisciplinary translational research challenge. Data "],"journal":["Stem cell reports"],"pagination":["1555-1572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10444572"],"repository":["biostudies-literature"],"pubmed_title":["Cell transplantation-based regenerative medicine in liver diseases."],"pmcid":["PMC10444572"],"pubmed_authors":["Orlando G","Pinzani M","Alvaro D","Lanthier N","Carpino G","Cardinale V","Carnevale G","Ciccocioppo R","Manzia TM","Angelico R","Uygun BE","Baptista PM","Schuppan D"],"additional_accession":[]},"is_claimable":false,"name":"Cell transplantation-based regenerative medicine in liver diseases.","description":"This review aims to evaluate the current preclinical state of liver bioengineering, the clinical context for liver cell therapies, the cell sources, the delivery routes, and the results of clinical trials for end-stage liver disease. Different clinical settings, such as inborn errors of metabolism, acute liver failure, chronic liver disease, liver cirrhosis, and acute-on-chronic liver failure, as well as multiple cellular sources were analyzed; namely, hepatocytes, hepatic progenitor cells, biliary tree stem/progenitor cells, mesenchymal stromal cells, and macrophages. The highly heterogeneous clinical scenario of liver disease and the availability of multiple cellular sources endowed with different biological properties make this a multidisciplinary translational research challenge. Data ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-04T08:54:31.591Z","creation":"2025-04-04T08:54:31.591Z"},"accession":"S-EPMC10444572","cross_references":{"pubmed":["37557073"],"doi":["10.1016/j.stemcr.2023.06.005"]}}