{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harrison LC"],"funding":["NHMRC Research Institute Infrastructure Support Scheme","The National Health and Medical Research Council of Australia","Diabetes South Australia","NHMRC Practitioner Fellowship","Juvenile Diabetes Research Foundation Australia and The Leona M. and Harry B. Helmsley Charitable Trust","Juvenile Diabetes Research Foundation Australia International Strategic Research Award scheme","NHMRC Investigator Fellowship","Victorian State Government Operational Infrastructure Support Scheme"],"pagination":["1092-1100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10445231"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["Aims/introduction
Autoantibodies to pancreatic islet antigens identify young children at high risk of type 1 diabetes. On a background of genetic susceptibility, islet autoimmunity is thought to be driven by environmental factors, of which enteric viruses are prime candidates. We sought evidence for enteric pathology in children genetically at-risk for type 1 diabetes followed from birth who had developed islet autoantibodies (\"seroconverted\"), by measuring mucosa-associated cytokines in their sera.Materials and methods
Sera were collected 3 monthly from birth from children with a first-degree type 1 diabetes relative, in the Environmental Determinants of Islet Autoimmunity (ENDIA) study. Children who seroconverted were matched for sex, age, and sample availability with ser"],"journal":["Journal of diabetes investigation"],"pubmed_title":["A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes."],"pmcid":["PMC10445231"],"funding_grant_id":["3-SRA-2019-899-M-N","APP1078106","APP1136735","APP1173945","3-SRA-2020-966-M-N","3-SRA-2017-417-A-N"],"pubmed_authors":["McGorm KJ","Morahan G","Ramoso B","Rawlinson WD","Stone NL","Ashwood P","Butterworth C","Battersby R","Hu W","Kim KW","Wong YY","Wentworth JM","Watson K","Huynh D","Tully A","Bezuidenhout D","Sinnott RO","Roth-Schulze A","Wu R","Hoffman M","Craig ME","Davis EA","Naselli G","Penno MAS","Huynh T","Gwiazdzinski A","Yau C","Gilbert A","Vicary I","Oakey H","Soldatos G","Gartrell K","Catteau J","Hulley A","Brown JD","Brandrick S","Binkowski S","Xu Y","Ward E","Sadlon T","Minhaj A","Hamilton-Williams E","Beresford S","Lopez P","Hope C","Penno MA","Clements N","Stone N","Tye-Din J","Harper G","Hall C","Kludas R","Bui M","Brittain B","Anderson AJ","Zozaya-Valdes E","Thomson RL","Harris M","Morbey C","Bertram S","Ngui K","Barry SC","Nguyen T","Harrison LC","Couper JJ","Colman PG","Vuillermin PJ","Haynes A","ENDIA Study Group","Roberts A","Bandala-Sanchez E","Moore B","Wood R","Griffiths H","Hamilton-Williams EE"],"additional_accession":[]},"is_claimable":false,"name":"A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes.","description":"Aims/introduction
Autoantibodies to pancreatic islet antigens identify young children at high risk of type 1 diabetes. On a background of genetic susceptibility, islet autoimmunity is thought to be driven by environmental factors, of which enteric viruses are prime candidates. We sought evidence for enteric pathology in children genetically at-risk for type 1 diabetes followed from birth who had developed islet autoantibodies (\"seroconverted\"), by measuring mucosa-associated cytokines in their sera.Materials and methods
Sera were collected 3 monthly from birth from children with a first-degree type 1 diabetes relative, in the Environmental Determinants of Islet Autoimmunity (ENDIA) study. Children who seroconverted were matched for sex, age, and sample availability with ser","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-26T06:26:41.785Z","creation":"2025-04-06T11:56:26.256Z"},"accession":"S-EPMC10445231","cross_references":{"pubmed":["37312283"],"doi":["10.1111/jdi.14031"]}}