{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Speakman JR"],"funding":["Intramural NIH HHS","NIDDK NIH HHS","NCI NIH HHS","CAS | Shenzhen Key Laboratory of Neuropsychiatric Modulation","Forskningsrådet om Hälsa, Arbetsliv och Välfärd","Wellcome Trust"],"pagination":["579-588"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10445668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(4)"],"pubmed_abstract":["Obesity is caused by a prolonged positive energy balance<sup>1,2</sup>. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated<sup>3,4</sup>. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition and age declined since the late 1980s, while adjusted activity energy expenditure increased over time. We use the International Atomic Energy Agency Doubly Labelled Water database on energy expenditure of adults in the United States and Europe (n = 4,799) to explore patterns in total (TEE: n = 4,799), basal (BEE: n = 1,432) and physical activity energy expenditure (n = 1,432) over time. In males, adjusted BEE decreased significantly, but in females this did not reach significance. A larger dataset of basal metabolic r"],"journal":["Nature metabolism"],"pubmed_title":["Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure."],"pmcid":["PMC10445668"],"funding_grant_id":["ZIA HD000641","VR 2018-06735","R03 DK122189","Z99 HD999999","IA/CRC/19/1/610006","R01 DK090489","R01 DK126447","K01 DK109079","R01 CA119171","CAS 153E11KYSB20190045"],"pubmed_authors":["Haisma HH","Arab L","Hu S","Stice E","Ravussin E","Redman LM","Cooper R","Kushner RF","Gurven M","Wood BM","Kaplan JL","Loechl CU","Schuit AJ","Sagayama H","Ojiambo RM","Camps SGJA","Pietilainen KH","Rood J","Urlacher SS","Joosen AM","Sardinha LB","Silva AM","Murphy-Alford AJ","Halsey LG","Bonomi AG","Sinha S","Anderson LJ","Davies PSW","Katzmarzyk P","Prentice RL","Luke AH","Yamada Y","Meijer EP","Bovet P","Rudolph MC","Kraus WE","Gillingham M","Pontzer H","Rodeheffer MS","Yanovski JA","Ainslie PN","Ekelund U","Valenti G","Van Mil EA","Dugas LR","Wong WW","Butte NF","Schoeller DA","Plasqui G","Das SK","Leonard WR","Martin CK","Raichlen DA","Van Etten LM","Bedu-Addo K","Forrester T","Speakman JR","Kurpad A","Entringer S","de Jong JMA","Roberts SB","Yoshida T","Brage S","Buchowski MS","Nicklas TA","Fudge BW","Blanc S","Hoffman D","Matsiko E","Westerterp KR","Ghosh S","Lof M","Hambly C","Zhang X","Plange-Rhule J","Neuhouser ML","Racette SB","Cooper JA","Goris AH","Medin AC"],"additional_accession":[]},"is_claimable":false,"name":"Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.","description":"Obesity is caused by a prolonged positive energy balance<sup>1,2</sup>. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated<sup>3,4</sup>. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition and age declined since the late 1980s, while adjusted activity energy expenditure increased over time. We use the International Atomic Energy Agency Doubly Labelled Water database on energy expenditure of adults in the United States and Europe (n = 4,799) to explore patterns in total (TEE: n = 4,799), basal (BEE: n = 1,432) and physical activity energy expenditure (n = 1,432) over time. In males, adjusted BEE decreased significantly, but in females this did not reach significance. A larger dataset of basal metabolic r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T09:24:50.118Z","creation":"2025-04-04T09:24:50.118Z"},"accession":"S-EPMC10445668","cross_references":{"pubmed":["37100994"],"doi":["10.1038/s42255-023-00782-2"]}}