{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McIntyre DC"],"funding":["American Cancer Society","NICHD NIH HHS","NCI NIH HHS","National Institutes of Health","NIH HHS","NIGMS NIH HHS"],"pagination":["dev201640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10445801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150(16)"],"pubmed_abstract":["Stem cell quiescence, proliferation and differentiation are controlled by interactions with niche cells and a specialized extracellular matrix called basement membrane (BM). Direct interactions with adjacent BM are known to regulate stem cell quiescence; however, it is less clear how niche BM relays signals to stem cells that it does not contact. Here, we examine how niche BM regulates Caenorhabditis elegans primordial germ cells (PGCs). BM regulates PGC quiescence even though PGCs are enwrapped by somatic niche cells and do not contact the BM; this can be demonstrated by depleting laminin, which causes normally quiescent embryonic PGCs to proliferate. We show that following laminin depletion, niche cells relay proliferation-inducing signals from the gonadal BM to PGCs via integrin recepto"],"journal":["Development (Cambridge, England)"],"pubmed_title":["Niche cells regulate primordial germ cell quiescence in response to basement membrane signaling."],"pmcid":["PMC10445801"],"funding_grant_id":["R35GM118081","R21 HD103989","P30 CA016087","R35 GM118081","PF-16-098-01-DDC","R21HD103989","P40 OD010440"],"pubmed_authors":["McIntyre DC","Nance J"],"additional_accession":[]},"is_claimable":false,"name":"Niche cells regulate primordial germ cell quiescence in response to basement membrane signaling.","description":"Stem cell quiescence, proliferation and differentiation are controlled by interactions with niche cells and a specialized extracellular matrix called basement membrane (BM). Direct interactions with adjacent BM are known to regulate stem cell quiescence; however, it is less clear how niche BM relays signals to stem cells that it does not contact. Here, we examine how niche BM regulates Caenorhabditis elegans primordial germ cells (PGCs). BM regulates PGC quiescence even though PGCs are enwrapped by somatic niche cells and do not contact the BM; this can be demonstrated by depleting laminin, which causes normally quiescent embryonic PGCs to proliferate. We show that following laminin depletion, niche cells relay proliferation-inducing signals from the gonadal BM to PGCs via integrin recepto","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T10:09:03.9Z","creation":"2025-04-05T10:09:03.9Z"},"accession":"S-EPMC10445801","cross_references":{"pubmed":["37497562"],"doi":["10.1242/dev.201640"]}}