{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(34)"],"submitter":["Sun R"],"pubmed_abstract":["Regulatory T (T<sub>reg</sub>) cells and cancer-associated fibroblasts (CAFs) jointly promote tumor immune tolerance and tumorigenesis. The molecular apparatus that drives T<sub>reg</sub> cell and CAF coordination in the tumor microenvironment (TME) remains elusive. Interleukin 33 (IL-33) has been shown to enhance fibrosis and IL1RL1<sup>+</sup> T<sub>reg</sub> cell accumulation during tumorigenesis and tissue repair. We demonstrated that IL1RL1 signaling in T<sub>reg</sub> cells greatly dampened the antitumor activity of both IL-33 and PD-1 blockade. Whole tumor single-cell RNA sequencing (scRNA-seq) analysis and blockade experiments revealed that the amphiregulin (AREG)-epidermal growth factor receptor (EGFR) axis mediated cross-talk between IL1RL1<sup>+</sup> T<sub>reg</sub> cells and C"],"journal":["Science advances"],"pagination":["eadd7399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10446484"],"repository":["biostudies-literature"],"pubmed_title":["Amphiregulin couples IL1RL1<sup>+</sup> regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity."],"pmcid":["PMC10446484"],"pubmed_authors":["Li H","Chen K","Lu X","Sun R","Chen L","Ni A","Gao DS","Zhao H","Lu B"],"additional_accession":[]},"is_claimable":false,"name":"Amphiregulin couples IL1RL1<sup>+</sup> regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity.","description":"Regulatory T (T<sub>reg</sub>) cells and cancer-associated fibroblasts (CAFs) jointly promote tumor immune tolerance and tumorigenesis. The molecular apparatus that drives T<sub>reg</sub> cell and CAF coordination in the tumor microenvironment (TME) remains elusive. Interleukin 33 (IL-33) has been shown to enhance fibrosis and IL1RL1<sup>+</sup> T<sub>reg</sub> cell accumulation during tumorigenesis and tissue repair. We demonstrated that IL1RL1 signaling in T<sub>reg</sub> cells greatly dampened the antitumor activity of both IL-33 and PD-1 blockade. Whole tumor single-cell RNA sequencing (scRNA-seq) analysis and blockade experiments revealed that the amphiregulin (AREG)-epidermal growth factor receptor (EGFR) axis mediated cross-talk between IL1RL1<sup>+</sup> T<sub>reg</sub> cells and C","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-26T23:29:40.35Z","creation":"2025-04-06T17:35:47.147Z"},"accession":"S-EPMC10446484","cross_references":{"pubmed":["37611111"],"doi":["10.1126/sciadv.add7399"]}}