biostudies-literatureMin YNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (National Science Foundation of China)5134https://www.ebi.ac.uk/biostudies/studies/S-EPMC10447495biostudies-literatureUnknown14(1)Electrochemical technology is a robust approach to removing toxic and persistent chlorinated organic pollutants from water; however, it remains a challenge to design electrocatalysts with high activity and selectivity as elaborately as natural reductive dehalogenases. Here we report the design of high-performance electrocatalysts toward water dechlorination by mimicking the binding pocket configuration and catalytic center of reductive dehalogenases. Specifically, our designed electrocatalyst is an assembled heterostructure by sandwiching a molecular catalyst into the interlayers of two-dimensional graphene oxide. The electrocatalyst exhibits excellent dechlorination performance, which enhances reduction of intermediate dichloroacetic acid by 7.8 folds against that without sandwich configuNature communicationsMimicking reductive dehalogenases for efficient electrocatalytic water dechlorination.PMC1044749522232003Xiong YPan XQMin YYu HQChen JJMei SCfalseMimicking reductive dehalogenases for efficient electrocatalytic water dechlorination.Electrochemical technology is a robust approach to removing toxic and persistent chlorinated organic pollutants from water; however, it remains a challenge to design electrocatalysts with high activity and selectivity as elaborately as natural reductive dehalogenases. Here we report the design of high-performance electrocatalysts toward water dechlorination by mimicking the binding pocket configuration and catalytic center of reductive dehalogenases. Specifically, our designed electrocatalyst is an assembled heterostructure by sandwiching a molecular catalyst into the interlayers of two-dimensional graphene oxide. The electrocatalyst exhibits excellent dechlorination performance, which enhances reduction of intermediate dichloroacetic acid by 7.8 folds against that without sandwich configu2023-01-01T00:00:00Z2023 Aug2026-04-29T02:32:34.567Z2025-02-19T04:02:12.311ZS-EPMC104474953761227510.1038/s41467-023-40906-6