biostudies-literatureUnknown16Huh E<h4>Introduction</h4>Parkinson's disease (PD) is a representative neurodegenerative disease, and its diagnosis relies on the evaluation of clinical manifestations or brain neuroimaging in the absence of a crucial noninvasive biomarker. Here, we used non-targeted metabolomics profiling to identify metabolic alterations in the colon and plasma samples of <i>Proteus mirabilis</i> (<i>P. mirabilis</i>)-treated mice, which is a possible animal model for investigating the microbiota-gut-brain axis.<h4>Methods</h4>We performed gas chromatography-mass spectrometry to analyze the samples and detected metabolites that could reflect <i>P. mirabilis</i>-induced disease progression and pathology.<h4>Results and discussion</h4>Pattern, correlation and pathway enrichment analyses showed significant alterFrontiers in molecular neuroscience1201073https://www.ebi.ac.uk/biostudies/studies/S-EPMC10447900biostudies-literaturePeripheral metabolic alterations associated with pathological manifestations of Parkinson's disease in gut-brain axis-based mouse model.PMC10447900Park MGKim DHEo HLee CHOh MSPark HJKim JHChoi YChoi JGJu IGHuh ELee MYfalsePeripheral metabolic alterations associated with pathological manifestations of Parkinson's disease in gut-brain axis-based mouse model.<h4>Introduction</h4>Parkinson's disease (PD) is a representative neurodegenerative disease, and its diagnosis relies on the evaluation of clinical manifestations or brain neuroimaging in the absence of a crucial noninvasive biomarker. Here, we used non-targeted metabolomics profiling to identify metabolic alterations in the colon and plasma samples of <i>Proteus mirabilis</i> (<i>P. mirabilis</i>)-treated mice, which is a possible animal model for investigating the microbiota-gut-brain axis.<h4>Methods</h4>We performed gas chromatography-mass spectrometry to analyze the samples and detected metabolites that could reflect <i>P. mirabilis</i>-induced disease progression and pathology.<h4>Results and discussion</h4>Pattern, correlation and pathway enrichment analyses showed significant alter2023-01-01T00:00:00Z20232025-07-02T03:04:38.13Z2025-04-19T23:16:27.623ZS-EPMC104479003763590410.3389/fnmol.2023.1201073