{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang J"],"funding":["National Natural Science Foundation of China","Natural Science Basic Research Program of Shaanxi Province"],"pagination":["107536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10448166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(9)"],"pubmed_abstract":["Prolonged withdrawal from opioids leads to negative emotions. Kappa opioid receptor (KOR) plays an important role in opioid addiction and affective disorders. However, the underlying mechanism of KOR in withdrawal-related depression is still lacking. We found that escitalopram treatment had a limited effect in improving depression symptoms in heroin-dependent patients. In mice, we demonstrated prolonged (4 weeks) but not acute (24 h) withdrawal from morphine induced depressive-like behaviors. The number of c-Fos positive cells and the expression of KOR in the nucleus accumbens (NAc), were significantly increased in the prolonged morphine withdrawal mice. Conditional KOR knockdown in NAc significantly improved depressive-like behaviors. Repeated but not acute treatment with the KOR antagoni"],"journal":["iScience"],"pubmed_title":["Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice."],"pmcid":["PMC10448166"],"funding_grant_id":["2021JM-027","82171880","2022JQ-783"],"pubmed_authors":["Sun L","Yin F","Zhang J","Tian W","Lu Y","Dong Z","Wei S","Jia M","Bai Y","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice.","description":"Prolonged withdrawal from opioids leads to negative emotions. Kappa opioid receptor (KOR) plays an important role in opioid addiction and affective disorders. However, the underlying mechanism of KOR in withdrawal-related depression is still lacking. We found that escitalopram treatment had a limited effect in improving depression symptoms in heroin-dependent patients. In mice, we demonstrated prolonged (4 weeks) but not acute (24 h) withdrawal from morphine induced depressive-like behaviors. The number of c-Fos positive cells and the expression of KOR in the nucleus accumbens (NAc), were significantly increased in the prolonged morphine withdrawal mice. Conditional KOR knockdown in NAc significantly improved depressive-like behaviors. Repeated but not acute treatment with the KOR antagoni","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-19T23:16:01.213Z","creation":"2025-04-19T23:16:01.213Z"},"accession":"S-EPMC10448166","cross_references":{"pubmed":["37636073"],"doi":["10.1016/j.isci.2023.107536"]}}