biostudies-literatureUnknown8(33)Li JMuscle atrophy often occurs in type 2 diabetes (T2D) and leads to an increase in physical disability and insulin resistance. However, there are very few studies that have investigated potential natural products used for this condition. In this study, we demonstrated that <i>FYGL</i> (Fudan-Yueyang-<i>G. lucidum</i>), a proteoglycan extracted from <i>Ganoderma lucidum</i>, ameliorated muscle atrophy in rat and mouse models of diabetes. Histopathological analysis of muscle revealed that oral administration of <i>FYGL</i> significantly prevented reduction of the cross-sectional area of muscle fibers and overexpression of muscle atrophic factors in diabetic rats and mice. Muscle RNA-seq analysis in vivo indicated that <i>FYGL</i> regulated genes related to myogenesis, muscle atrophy, and oxidaACS omega30359-30373https://www.ebi.ac.uk/biostudies/studies/S-EPMC10448640biostudies-literatureProteoglycan Extracted from <i>Ganoderma lucidum</i> Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.PMC10448640Yang HLi JPan YHe YZhang ZZhou PZhang YYu FfalseProteoglycan Extracted from <i>Ganoderma lucidum</i> Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.Muscle atrophy often occurs in type 2 diabetes (T2D) and leads to an increase in physical disability and insulin resistance. However, there are very few studies that have investigated potential natural products used for this condition. In this study, we demonstrated that <i>FYGL</i> (Fudan-Yueyang-<i>G. lucidum</i>), a proteoglycan extracted from <i>Ganoderma lucidum</i>, ameliorated muscle atrophy in rat and mouse models of diabetes. Histopathological analysis of muscle revealed that oral administration of <i>FYGL</i> significantly prevented reduction of the cross-sectional area of muscle fibers and overexpression of muscle atrophic factors in diabetic rats and mice. Muscle RNA-seq analysis in vivo indicated that <i>FYGL</i> regulated genes related to myogenesis, muscle atrophy, and oxida2023-01-01T00:00:00Z2023 Aug2026-05-28T23:12:15.446Z2024-11-09T11:13:32.983ZS-EPMC104486403763697110.1021/acsomega.3c03513