{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lenz B"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Zentralinstitut für Seelische Gesundheit (ZI)"],"pagination":["1243-1254"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10449726"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["273(6)"],"pubmed_abstract":["Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D "],"journal":["European archives of psychiatry and clinical neuroscience"],"pubmed_title":["Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents."],"pmcid":["PMC10449726"],"funding_grant_id":["01GL1745B","402170461 – TRR265","402170461 - TRR265"],"pubmed_authors":["Banaschewski T","Flor H","IMAC-Mind Consortium","Fasching PA","Gerhardt S","Guldner S","Boroumand-Jazi R","Prignitz M","Nees F","Lenz B","Buchholz VN","Kornhuber J","Eichler A"],"additional_accession":[]},"is_claimable":false,"name":"Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents.","description":"Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-18T18:47:21.45Z","creation":"2025-04-07T06:30:46.906Z"},"accession":"S-EPMC10449726","cross_references":{"pubmed":["36449103"],"doi":["10.1007/s00406-022-01515-4"]}}