biostudies-literatureUnknown13Yan D<h4>Background</h4>The rapid increase in electronic nicotine product (ENP) use among young people has been a global public health challenge, given the potential harm of ENPs and nicotine dependence. Many countries have recently introduced legislations to regulate ENPs, but the impacts of these policies are poorly understood. This systematic review aims to critically synthesise empirical studies on the effects of global regulations regarding ENPs on the prevalence of use, health outcomes and their determinants, using the 4A marketing mix framework (acceptability, affordability, accessibility and awareness).<h4>Methods</h4>Following the PRISMA guideline, we searched PubMed, Embase, Scopus, Web of Science, Academic Search Complete, Business Source Complete, and APA PsycINFO databases from incJournal of global health04076https://www.ebi.ac.uk/biostudies/studies/S-EPMC10451104biostudies-literatureA systematic review for the impacts of global approaches to regulating electronic nicotine products.PMC10451104Bhuyan SSYan ALv XZhang XYan DWilson FALaestadius LWang YWang ZMosalpuria KfalseA systematic review for the impacts of global approaches to regulating electronic nicotine products.<h4>Background</h4>The rapid increase in electronic nicotine product (ENP) use among young people has been a global public health challenge, given the potential harm of ENPs and nicotine dependence. Many countries have recently introduced legislations to regulate ENPs, but the impacts of these policies are poorly understood. This systematic review aims to critically synthesise empirical studies on the effects of global regulations regarding ENPs on the prevalence of use, health outcomes and their determinants, using the 4A marketing mix framework (acceptability, affordability, accessibility and awareness).<h4>Methods</h4>Following the PRISMA guideline, we searched PubMed, Embase, Scopus, Web of Science, Academic Search Complete, Business Source Complete, and APA PsycINFO databases from inc2023-01-01T00:00:00Z2023 Aug2025-05-29T21:46:31.085Z2024-11-09T00:37:54.031ZS-EPMC104511043762272110.7189/jogh.13.04076