biostudies-literatureUnknown13(8)Li ZMedical Science and Technology Program of NanjingNational Nature Science Foundation of ChinaBackground: Stroke-associated pneumonia (SAP) is a common stroke complication, and the changes in the gut microbiota composition may play a role. Our study aimed to evaluate the predictive ability of gut microbiota for SAP. Methods: Acute ischemic stroke patients were prospectively enrolled and divided into two groups based on the presence or absence of SAP. The composition of gut microbiota was characterized by the 16S RNA Miseq sequencing. The gut microbiota that differed significantly between groups were incorporated into the conventional risk scores, the Acute Ischemic Stroke-Associated Pneumonia Score (AIS-APS), and the Age, Atrial fibrillation, Dysphagia, Sex, Stroke Severity Score (A2DS2). The predictive performances were assessed in terms of the area under the curve (AUC), the Net Brain scienceshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10452830biostudies-literatureThe Potential of Gut Microbiota in Prediction of Stroke-Associated PneumoniaPMC1045283081701064JQX20007Li ZZhang YGu MChen XSun HZhou JfalseThe Potential of Gut Microbiota in Prediction of Stroke-Associated PneumoniaBackground: Stroke-associated pneumonia (SAP) is a common stroke complication, and the changes in the gut microbiota composition may play a role. Our study aimed to evaluate the predictive ability of gut microbiota for SAP. Methods: Acute ischemic stroke patients were prospectively enrolled and divided into two groups based on the presence or absence of SAP. The composition of gut microbiota was characterized by the 16S RNA Miseq sequencing. The gut microbiota that differed significantly between groups were incorporated into the conventional risk scores, the Acute Ischemic Stroke-Associated Pneumonia Score (AIS-APS), and the Age, Atrial fibrillation, Dysphagia, Sex, Stroke Severity Score (A2DS2). The predictive performances were assessed in terms of the area under the curve (AUC), the Net 2023-01-01T00:00:00Z2023 Aug2025-04-27T02:38:44.222Z2025-04-06T18:40:02.285ZS-EPMC10452830