{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mitsueda R"],"funding":["KAKENHI","Naoko Kikkawa","Mayuko Kato","Naohiko Seki","Hiroko Toda","Yoshiaki Shinden"],"pagination":["4189"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10453418"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(16)"],"pubmed_abstract":["Accumulating evidence suggests that the <i>miR-30</i> family act as critical players (tumor-suppressor or oncogenic) in a wide range of human cancers. Analysis of microRNA (miRNA) expression signatures and The Cancer Genome Atlas (TCGA) database revealed that that two passenger strand miRNAs, <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>, were downregulated in cancer tissues, and their low expression was closely associated with worse prognosis in patients with BrCa. Functional assays showed that <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i> overexpression significantly inhibited cancer cell aggressiveness, suggesting these two miRNAs acted as tumor-suppressors in BrCa cells. Notably, involvement of passenger strands of miRNAs is a new concept of cancer research. Further analyses showed that se"],"journal":["Cancers"],"pubmed_title":["Oncogenic Targets Regulated by Tumor-Suppressive <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>: <i>TRIP13</i> Facilitates Cancer Cell Aggressiveness in Breast Cancer."],"pmcid":["PMC10453418"],"funding_grant_id":["22K08705","21K09577","22K09679","21K09367","23K08094"],"pubmed_authors":["Fukuda K","Toda H","Shinden Y","Yasudome R","Kato M","Mitsueda R","Nakajo A","Kikkawa N","Ohtsuka T","Seki N"],"additional_accession":[]},"is_claimable":false,"name":"Oncogenic Targets Regulated by Tumor-Suppressive <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>: <i>TRIP13</i> Facilitates Cancer Cell Aggressiveness in Breast Cancer.","description":"Accumulating evidence suggests that the <i>miR-30</i> family act as critical players (tumor-suppressor or oncogenic) in a wide range of human cancers. Analysis of microRNA (miRNA) expression signatures and The Cancer Genome Atlas (TCGA) database revealed that that two passenger strand miRNAs, <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>, were downregulated in cancer tissues, and their low expression was closely associated with worse prognosis in patients with BrCa. Functional assays showed that <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i> overexpression significantly inhibited cancer cell aggressiveness, suggesting these two miRNAs acted as tumor-suppressors in BrCa cells. Notably, involvement of passenger strands of miRNAs is a new concept of cancer research. Further analyses showed that se","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-06-23T03:13:05.058Z","creation":"2025-04-07T10:19:10.405Z"},"accession":"S-EPMC10453418","cross_references":{"pubmed":["37627217"],"doi":["10.3390/cancers15164189"]}}