biostudies-literatureMitsueda RKAKENHINaoko KikkawaMayuko KatoNaohiko SekiHiroko TodaYoshiaki Shinden4189https://www.ebi.ac.uk/biostudies/studies/S-EPMC10453418biostudies-literatureUnknown15(16)Accumulating evidence suggests that the <i>miR-30</i> family act as critical players (tumor-suppressor or oncogenic) in a wide range of human cancers. Analysis of microRNA (miRNA) expression signatures and The Cancer Genome Atlas (TCGA) database revealed that that two passenger strand miRNAs, <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>, were downregulated in cancer tissues, and their low expression was closely associated with worse prognosis in patients with BrCa. Functional assays showed that <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i> overexpression significantly inhibited cancer cell aggressiveness, suggesting these two miRNAs acted as tumor-suppressors in BrCa cells. Notably, involvement of passenger strands of miRNAs is a new concept of cancer research. Further analyses showed that seCancersOncogenic Targets Regulated by Tumor-Suppressive <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>: <i>TRIP13</i> Facilitates Cancer Cell Aggressiveness in Breast Cancer.PMC1045341822K0870521K0957722K0967921K0936723K08094Fukuda KToda HShinden YYasudome RKato MMitsueda RNakajo AKikkawa NOhtsuka TSeki NfalseOncogenic Targets Regulated by Tumor-Suppressive <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>: <i>TRIP13</i> Facilitates Cancer Cell Aggressiveness in Breast Cancer.Accumulating evidence suggests that the <i>miR-30</i> family act as critical players (tumor-suppressor or oncogenic) in a wide range of human cancers. Analysis of microRNA (miRNA) expression signatures and The Cancer Genome Atlas (TCGA) database revealed that that two passenger strand miRNAs, <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i>, were downregulated in cancer tissues, and their low expression was closely associated with worse prognosis in patients with BrCa. Functional assays showed that <i>miR-30c-1-3p</i> and <i>miR-30c-2-3p</i> overexpression significantly inhibited cancer cell aggressiveness, suggesting these two miRNAs acted as tumor-suppressors in BrCa cells. Notably, involvement of passenger strands of miRNAs is a new concept of cancer research. Further analyses showed that se2023-01-01T00:00:00Z2023 Aug2026-06-23T03:13:05.058Z2025-04-07T10:19:10.405ZS-EPMC104534183762721710.3390/cancers15164189