{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(16)"],"submitter":["Hirano Y"],"pubmed_abstract":["We previously demonstrated that neural stem/progenitor cells (NSPCs) were induced within and around the ischemic areas in a mouse model of ischemic stroke. These injury/ischemia-induced NSPCs (iNSPCs) differentiated to electrophysiologically functional neurons in vitro, indicating the presence of a self-repair system following injury. However, during the healing process after stroke, ischemic areas were gradually occupied by inflammatory cells, mainly microglial cells/macrophages (MGs/MΦs), and neurogenesis rarely occurred within and around the ischemic areas. Therefore, to achieve neural regeneration by utilizing endogenous iNSPCs, regulation of MGs/MΦs after an ischemic stroke might be necessary. To test this hypothesis, we used iNSPCs isolated from the ischemic areas after a stroke in o"],"journal":["Cells"],"pagination":["2040"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10453473"],"repository":["biostudies-literature"],"pubmed_title":["Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains."],"pmcid":["PMC10453473"],"pubmed_authors":["Kubo S","Sakagami M","Sawano T","Nakano-Doi A","Minato Y","Nakagomi T","Tsuzuki K","Hirano Y"],"additional_accession":[]},"is_claimable":false,"name":"Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains.","description":"We previously demonstrated that neural stem/progenitor cells (NSPCs) were induced within and around the ischemic areas in a mouse model of ischemic stroke. These injury/ischemia-induced NSPCs (iNSPCs) differentiated to electrophysiologically functional neurons in vitro, indicating the presence of a self-repair system following injury. However, during the healing process after stroke, ischemic areas were gradually occupied by inflammatory cells, mainly microglial cells/macrophages (MGs/MΦs), and neurogenesis rarely occurred within and around the ischemic areas. Therefore, to achieve neural regeneration by utilizing endogenous iNSPCs, regulation of MGs/MΦs after an ischemic stroke might be necessary. To test this hypothesis, we used iNSPCs isolated from the ischemic areas after a stroke in o","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-26T23:41:45.212Z","creation":"2025-04-06T17:34:53.577Z"},"accession":"S-EPMC10453473","cross_references":{"pubmed":["37626850"],"doi":["10.3390/cells12162040"]}}