{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(15)"],"submitter":["Zeng D"],"pubmed_abstract":["N<sup>1</sup>-methyladenosine (m<sup>1</sup>A) is an essential chemical modification of RNA. Dysregulation of RNA m<sup>1</sup>A modification and m<sup>1</sup>A-related regulators is detected in several adult tumors. Whether aberrant RNA m<sup>1</sup>A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m<sup>1</sup>A modification. Some evidence has shown that genetic variants of <i>TRMT61B</i> might contribute to cancer susceptibility; however, its roles in hepatoblastoma are unknown. This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the <i>TRMT61B</i> rs4563180 G>C polymorphism among germline DNA samples from 313 cas"],"journal":["Aging"],"pagination":["7583-7592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10457066"],"repository":["biostudies-literature"],"pubmed_title":["<i>TRMT61B</i> rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers."],"pmcid":["PMC10457066"],"pubmed_authors":["Yang Z","Li Y","Li J","Zhu J","Liao F","Li S","Zhang J","He J","Li L","Zeng D","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"<i>TRMT61B</i> rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.","description":"N<sup>1</sup>-methyladenosine (m<sup>1</sup>A) is an essential chemical modification of RNA. Dysregulation of RNA m<sup>1</sup>A modification and m<sup>1</sup>A-related regulators is detected in several adult tumors. Whether aberrant RNA m<sup>1</sup>A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m<sup>1</sup>A modification. Some evidence has shown that genetic variants of <i>TRMT61B</i> might contribute to cancer susceptibility; however, its roles in hepatoblastoma are unknown. This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the <i>TRMT61B</i> rs4563180 G>C polymorphism among germline DNA samples from 313 cas","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-05-28T12:17:10.028Z","creation":"2025-04-07T10:22:22.255Z"},"accession":"S-EPMC10457066","cross_references":{"pubmed":["37531210"],"doi":["10.18632/aging.204926"]}}