biostudies-literatureUnknown15(15)Zeng DN¹-methyladenosine (m¹A) is an essential chemical modification of RNA. Dysregulation of RNA m¹A modification and m¹A-related regulators is detected in several adult tumors. Whether aberrant RNA m¹A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m¹A modification. Some evidence has shown that genetic variants of <i>TRMT61B</i> might contribute to cancer susceptibility; however, its roles in hepatoblastoma are unknown. This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the <i>TRMT61B</i> rs4563180 G>C polymorphism among germline DNA samples from 313 casAging7583-7592https://www.ebi.ac.uk/biostudies/studies/S-EPMC10457066biostudies-literature<i>TRMT61B</i> rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.PMC10457066Yang ZLi YLi JZhu JLiao FLi SZhang JHe JLi LZeng DCheng Jfalse<i>TRMT61B</i> rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.N¹-methyladenosine (m¹A) is an essential chemical modification of RNA. Dysregulation of RNA m¹A modification and m¹A-related regulators is detected in several adult tumors. Whether aberrant RNA m¹A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m¹A modification. Some evidence has shown that genetic variants of <i>TRMT61B</i> might contribute to cancer susceptibility; however, its roles in hepatoblastoma are unknown. This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the <i>TRMT61B</i> rs4563180 G>C polymorphism among germline DNA samples from 313 cas2023-01-01T00:00:00Z2023 Aug2026-05-28T12:17:10.028Z2025-04-07T10:22:22.255ZS-EPMC104570663753121010.18632/aging.204926