{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66"],"submitter":["Luna-Marco C"],"pubmed_abstract":["<h4>Objective</h4>Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development and cardiovascular diseases (CVDs). The aim was to investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, mitochondrial respiration, leukocyte-endothelial interactions, inflammation and carotid intima-media thickness (CIMT) in T2D patients.<h4>Research design and methods</h4>Type 2 diabetic patients (255) and control subjects (175) were recruited, paired by age and sex, and separated into two groups: without GLP-1 RA treatment (196) and treated with GLP-1 RA (59). Peripheral blood polymorphonuclear leukocytes (PMNs) were isolated to measure reactive oxygen species (ROS) production by flow cytometry and oxy"],"journal":["Redox biology"],"pagination":["102849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10457591"],"repository":["biostudies-literature"],"pubmed_title":["Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes."],"pmcid":["PMC10457591"],"pubmed_authors":["Rocha M","Sola E","de Maranon AM","Rodriguez-Hernandez Y","Vila J","Fernandez-Reyes M","Rovira-Llopis S","Morillas C","Luna-Marco C","Apostolova N","Victor VM","Hermenejildo J","Hermo-Argibay A"],"additional_accession":[]},"is_claimable":false,"name":"Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes.","description":"<h4>Objective</h4>Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development and cardiovascular diseases (CVDs). The aim was to investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, mitochondrial respiration, leukocyte-endothelial interactions, inflammation and carotid intima-media thickness (CIMT) in T2D patients.<h4>Research design and methods</h4>Type 2 diabetic patients (255) and control subjects (175) were recruited, paired by age and sex, and separated into two groups: without GLP-1 RA treatment (196) and treated with GLP-1 RA (59). Peripheral blood polymorphonuclear leukocytes (PMNs) were isolated to measure reactive oxygen species (ROS) production by flow cytometry and oxy","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-18T18:48:22.221Z","creation":"2025-04-07T06:27:52.01Z"},"accession":"S-EPMC10457591","cross_references":{"pubmed":["37591012"],"doi":["10.1016/j.redox.2023.102849"]}}