biostudies-literatureUnknown66Luna-Marco C<h4>Objective</h4>Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development and cardiovascular diseases (CVDs). The aim was to investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, mitochondrial respiration, leukocyte-endothelial interactions, inflammation and carotid intima-media thickness (CIMT) in T2D patients.<h4>Research design and methods</h4>Type 2 diabetic patients (255) and control subjects (175) were recruited, paired by age and sex, and separated into two groups: without GLP-1 RA treatment (196) and treated with GLP-1 RA (59). Peripheral blood polymorphonuclear leukocytes (PMNs) were isolated to measure reactive oxygen species (ROS) production by flow cytometry and oxyRedox biology102849https://www.ebi.ac.uk/biostudies/studies/S-EPMC10457591biostudies-literatureEffects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes.PMC10457591Rocha MSola Ede Maranon AMRodriguez-Hernandez YVila JFernandez-Reyes MRovira-Llopis SMorillas CLuna-Marco CApostolova NVictor VMHermenejildo JHermo-Argibay AfalseEffects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes.<h4>Objective</h4>Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development and cardiovascular diseases (CVDs). The aim was to investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, mitochondrial respiration, leukocyte-endothelial interactions, inflammation and carotid intima-media thickness (CIMT) in T2D patients.<h4>Research design and methods</h4>Type 2 diabetic patients (255) and control subjects (175) were recruited, paired by age and sex, and separated into two groups: without GLP-1 RA treatment (196) and treated with GLP-1 RA (59). Peripheral blood polymorphonuclear leukocytes (PMNs) were isolated to measure reactive oxygen species (ROS) production by flow cytometry and oxy2023-01-01T00:00:00Z2023 Aug2025-04-18T18:48:22.221Z2025-04-07T06:27:52.01ZS-EPMC104575913759101210.1016/j.redox.2023.102849